Sökning: "neurofibrillary tangles"

Visar resultat 1 - 5 av 59 avhandlingar innehållade orden neurofibrillary tangles.

  1. 1. Amyloid Maturation Patterns in Alzheimer's Disease - Novel chemical imaging of Aβ and Tau pathology

    Författare :Srinivas Koutarapu; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid β; Neurofibrillary Tangles; matrix-assisted laser desorption ionization-mass spectrometry imaging MALDI-MSI ; luminescent conjugated oligothiophenes; Alzheimer’s Disease; Neurodegeneration;

    Sammanfattning : Alzheimer’s disease (AD) accounts for approximately 70% of dementia cases in Sweden. It can be of genetic origin i.e. familial form (fAD), sporadic form (sAD). LÄS MER

  3. 2. Alzheimer's disease : towards a multifaceted approach in neuropathological diagnosis

    Författare :Nenad Bogdanovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; CERAD; neurofibrillary tangles. neuritic plaques; apoE. synaptic proteins; rab3a; synaptophysin; synaptotagmin; GAP-43; neurogranin; neuronal degeneration; optical disector 1998;

    Sammanfattning : The main aim of this study has been to investigate potential neuropathological features which may play an important role in understanding the cognitive dysfunction and in making the final diagnosis of Alzheimer's disease (AD). To establish a reliable diagnosis of AD, standardisation and uniformity of the diagnostic protocols must become mandatory. LÄS MER

  4. 3. The principal inferior olivary nucleus in aging and Alzheimer’s disease

    Författare :Helen Lasn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuronal degeneration is a commanding event in Alzheimer’s disease (AD). Neuronal loss is one of the major hallmarks and is frequently reported in regions with presence of neuritic plaques (NPs) and neurofibrillary tangles (NFTs). LÄS MER

  5. 4. Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies

    Författare :Claudia Cicognola; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tau; fragments; Alzheimer s disease; tauopathy; cerebrospinal fluid;

    Sammanfattning : Abstract Tau protein is physiologically expressed in neurons, where it is involved in microtubule assembly and stability. Tau functions are rigorously regulated by a series of modifications, e.g. phosphorylation and dephosphorylation. LÄS MER

  7. 5. Inflammatory cytokines and NFκB in Alzheimer’s disease

    Författare :Linda Fisher; Kerstin Iverfeldt; Illana Gozes; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-amyloid; interleukin-1; interleukin-6; cell-penetrating peptide; PNA; Neurochemistry; Neurokemi;

    Sammanfattning : Alzheimer’s disease is the most common form of dementia. It is a neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles. The main constituent of the senile plaques is the neurotoxic β-amyloid peptide. LÄS MER