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Visar resultat 11 - 15 av 28 avhandlingar som matchar ovanstående sökkriterier.
11. Dosimetry of Radionuclide Therapy with 177Lu-octreotate
Sammanfattning : In radionuclide therapy it is still common to administer standard activities or to scale administered activity with blunt parameters such as body weight or surface area. This is not ideal because, due to considerable variation in kinetics, large safety margins have to be applied to avoid radiation damage to healthy organs, which causes under-treatment of many patients. LÄS MER
12. Prognostic factors in prostate cancer with special reference to the effect of hormonal therapy
Sammanfattning : We have used image cell analysis to analyse nuclear DNA content on fine needle aspiration biopsies from 96 patients diagnosed to have prostate cancer 1980-81. By stratifying diploid and tetraploid tumours according to a cytometric proliferation index (PI), we suggest a new DNA-classification that is prognostic of death from prostate cancer in multivariate analysis including conventional prognostic factors. LÄS MER
13. Targeted radionuclide therapy for patients with neuroendocrine tumours with focus on normal tissue response in 177-Lu-DOTATATE treatment
Sammanfattning : Targeted radionuclide therapy with 177Lu-DOTATATE for patients with neuroendocrine tumours utilises the frequent overexpressing of somatostatin receptors on the tumour cells. This treatment modality has demonstrated valuable patient benefits and is well tolerated. However, renal and bone marrow toxicity can become dose limiting and persisting. LÄS MER
14. 177Lu-DOTA-octreotate Radionuclide Therapy of Neuroendocrine Tumours : Dosimetry-Based Therapy Planning and Outcome
Sammanfattning : Peptide receptor radionuclide therapy for the internal radiation of neuroendocrine tumours expressing somatostatin receptors has made great advances and offers promising results. 177Lu-DOTA-octreotate is one of the most widely used radiopeptides, but kidneys and bone marrow are organs at risk. LÄS MER
15. Gastrointestinal stromal tumours. On diagnosis and treatment
Sammanfattning : Gastrointestinal stromal tumours (GIST) are thought to originate from the interstitial cells of Cajal, which show many properties in common with neurons of the gastrointestinal tract. High-risk GIST has a very poor prognosis and tumour recurrence is common after intentionally curative surgery. LÄS MER