Sökning: "neuroblastom"
Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet neuroblastom.
1. Förbättrad radionuklidterapi av neuroblastom
Sammanfattning : Today, about half of the children diagnosed with high-risk neuroblastoma (HR-NB) survive due to considerable treatment improvements during the last decades. However, there is still much to be done for the other half who are not cured with current treatments. LÄS MER
2. Transcriptional regulation in neuroblastoma cells under normoxic and hypoxic conditions
Sammanfattning : The childhood malignancy neuroblastoma develops from early cells of the sympathetic nervous system (SNS), and the tumors often produce catecholamines. Neuroblastoma cells retain several characteristics of immature sympathetic cells including the expression of a number of transcription factors normally expressed during embryogenesis. LÄS MER
3. bHLH transcription factors in differentiating neuroblastoma cells
Sammanfattning : Neuroblastoma is a tumor of the sympathetic nervous system, and arises during early childhood. The tumor is highly heterogeneous and evidence, such as expression of genes normally only expressed during embryonic and fetal stages, suggests that the tumor is of embryonic origin and that the tumor arises as a consequence of perturbed differentiation during the development of the sympathetic nervous system. LÄS MER
4. IGF, PI3K and HIF-2 in Normal and Tumor Development
Sammanfattning : Cells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. LÄS MER
5. Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes
Sammanfattning : In this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. LÄS MER