Sökning: "neuroblast"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet neuroblast.

  1. 1. Stem cell based therapy of malignant brain tumors

    Författare :Daniel Bexell; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural stem cell; pericyte; mesenchymal stem cell; neuroblast; subventricular zone; cancer stem cell; rat; glioma; cancer;

    Sammanfattning : Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. LÄS MER

  3. 2. Exploring inter- and intra-heterogeneity in childhood neuroblastoma and pheochromocytoma

    Författare :Wenyu Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma is the most common extra-cranial solid tumor of the sympathoadrenal cell lineage, which is a unique pediatric malignancy with remarkable inter- and intra-tumoral heterogeneity. In infants, neuroblastoma can regress spontaneously without treatment, while in older patients, neuroblastoma can develop with lethal progression with less than a 50% survival rate. LÄS MER

  4. 3. Genetic mechanisms behind cell specification in the Drosophila CNS

    Författare :Magnus Baumgardt; Stefan Thor; Angela Giangrande; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; nervous system development; cell specification; stem cells; cell proliferation; combinatorial coding; feedforward loop; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : The human central nervous system (CNS) contains a daunting number of cells and tremendous cellular diversity. A fundamental challenge of developmental neurobiology is to address the questions of how so many different types of neurons and glia can be generated at the precise time and place, making precisely the right connections. LÄS MER

  5. 4. Specification of unique neuronal sub-types by integration of positional and temporal cues

    Författare :Daniel Karlsson; Stefan Thor; Mattias Alenius; Jeremy S. Dasen; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The nervous system contains vast numbers of neuronal sub-types, generated at specific time points, in the proper location, and in proper numbers. One of the fundamental issues in neurobiology is to understand the molecular genetic mechanisms that underlie the generation of this daunting neuronal diversity. LÄS MER

  7. 5. Neural Progenitor Cells in malignancy and injury of the brain. A Trojan Horse fro gliomas?

    Författare :Karin Staflin; CNS Genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; Immunologi; Medicine human and vertebrates ; Medicin människa och djur ; Immunology; serology; Glioma; sub ventricular zone; neural progenitor cell;

    Sammanfattning : Gliomas are neoplasms arising in the central nervous system (CNS), and constitute the most common primary brain tumor. They are classified depending on the grade and morphology, from grade I, pilocytic astrocytoma, to grade IV, glioblastoma multiforme (GBM). Glioblastomas constitute a great challenge in treatment due to their disseminating nature. LÄS MER