Sökning: "neuroactive steroids"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden neuroactive steroids.

  1. 1. Neuroactive steroids and rat CNS

    Författare :Vita Birzniece; Bo Söderpalm; Umeå universitet; []
    Nyckelord :Estradiol; progesterone; HRT; allopregnanolone; UC1011; serotonin receptor; GABAA receptor; mRNA; Morris water maze; silent second; tolerance; Clinical Neurophysiology; klinisk neurofysiologi;

    Sammanfattning : Several studies suggest profound effects on mood and cognition by neuroactive steroids. Estrogen alone or in combination with antidepressant drugs affecting the serotonin system has been used to treat mood disorders. On the other hand, progesterone is related to negative effects on mood and memory. LÄS MER

  3. 2. Effects of neuroactive steroids on the recombinant GABAA receptor in Xenopus oocyte

    Författare :Mozibur Rahman; Ming-De Wang; Bjarke Ebert; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; GABA; GABAA receptor; neuroactive steroids; Obstetrics and gynaecology; Obstetrik och gynekologi;

    Sammanfattning : Introduction: Neuroactive steroids represent a class of both synthetic and naturally occurring steroids that have an effect on neural function. In addition to classical genomic mechanism by the hormones progesterone, deoxycorticosterone and testosterone 3α-OH metabolites of these hormones enhance GABAA receptor through rapid non-genomic mechanism. LÄS MER

  4. 3. Premenstrual dysphoric disorder in relation to neuroactive steroids and alcohol

    Författare :Sigrid Nyberg; Britth-Marie Landgren; Umeå universitet; []
    Nyckelord :premenstrual dysphoric disorder; GnRH-agonist; progesterone; allopregnanolone; alcohol; saccadic eye velocity; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Introduction: Premenstrual Dysphoric Disorder (PMDD) is a condition that affects about 2-6% of women of reproductive age. The relation to ovarian steroids is apparent as symptoms are absent during anovulatory cycles. LÄS MER

  5. 4. Sex and stress steroid modulation of GABA mediated chloride ion flux in rat CNS

    Författare :Jessica Strömberg; Per Lundgren; Torbjörn Bäckström; David Haage; Esa Korpi; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; allopregnanolone; chloride ion uptake; patch-clamp; 3beta-steroids; kinetic parameters; rat brain; Obstetrics and gynaecology; Obstetrik och gynekologi;

    Sammanfattning : Background: Sex and stress steroids are metabolized to 3a-hydroxy-pregnane-steroid metabolites such as allopregnanolone (Allo) and tetrahydrodeoxycorticosterone (THDOC). Allo and THDOC are neuroactive steroids that are metabolized in the brain and act in brain as potent positive GABAA receptor function modulators. LÄS MER

  7. 5. Hormones, Mood and Cognition

    Författare :Kristiina Kask; Inger Sundström Poromaa; Torbjörn Bäckström; Britth-Marie Landgren; Uppsala universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; startle response; prepulse inhibition; premenstrual dysphoric disorder; menstrual cycle; pregnancy; postpartum period; episodic memory; semantic memory; working memory; progesterone; estradiol; allopregnanolone.; Obstetrics and gynaecology; Obstetrik och gynekologi;

    Sammanfattning : Ovarian steroid hormones are neuroactive steroids with widespread actions in the brain, and are thus able to influence mood, behavior and cognition. In this thesis the effects of progesterone withdrawal and the direct effects of the progesterone metabolite allopregnanolone are evaluated. LÄS MER