Sökning: "neuritic"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet neuritic.

  1. 1. Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease

    Författare :Wen-Feng Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Abeta; Alzheimer s disease; astrocytes; brain development; nAChRs; neuritic plaques oxidative stress; transgenic mice; knockout mice;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia with pathological features including the accumulation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs). These degenerative processes are also accompanied by impaired cholinergic transmission, oxidative stress, activated glia and inflammation reaction. LÄS MER

  3. 2. Alzheimer's disease : towards a multifaceted approach in neuropathological diagnosis

    Författare :Nenad Bogdanovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; CERAD; neurofibrillary tangles. neuritic plaques; apoE. synaptic proteins; rab3a; synaptophysin; synaptotagmin; GAP-43; neurogranin; neuronal degeneration; optical disector 1998;

    Sammanfattning : The main aim of this study has been to investigate potential neuropathological features which may play an important role in understanding the cognitive dysfunction and in making the final diagnosis of Alzheimer's disease (AD). To establish a reliable diagnosis of AD, standardisation and uniformity of the diagnostic protocols must become mandatory. LÄS MER

  4. 3. The involvement of degradation pathways and neuron-to-neuron transmission in Alzheimer’s disease

    Författare :Lotta Agholme; Martin Hallbeck; Katarina Kågedal; Jan Marcusson; Gunnar Gouras; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Although the vast majority of Alzheimer’s disease (AD) cases are of the sporadic type, mutations causing the familial form have been the focus of AD research for decades. The disease is pathologically characterised by β-amyloid (Aβ) and tau protein aggregates in neuritic plaques and neurofibrillary tangles. LÄS MER

  5. 4. Amyloid Maturation Patterns in Alzheimer's Disease - Novel chemical imaging of Aβ and Tau pathology

    Författare :Srinivas Koutarapu; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid β; Neurofibrillary Tangles; matrix-assisted laser desorption ionization-mass spectrometry imaging MALDI-MSI ; luminescent conjugated oligothiophenes; Alzheimer’s Disease; Neurodegeneration;

    Sammanfattning : Alzheimer’s disease (AD) accounts for approximately 70% of dementia cases in Sweden. It can be of genetic origin i.e. familial form (fAD), sporadic form (sAD). LÄS MER

  7. 5. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects

    Författare :Elena V. Ivanova; Kerstin Iverfeldt; Boris Zhivotovsky; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; caspase; local caspase activation; neurodegeneration; tau-anchored FRET sensors; tAFS; cancer; neuroblastoma; TNF-related apoptosis inducing ligand; TRAIL; protein kinase C; PKC; X-linked inhibitor of apoptosis protein; XIAP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. LÄS MER