Sökning: "neural stem"

Visar resultat 21 - 25 av 264 avhandlingar innehållade orden neural stem.

  1. 21. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology

    Författare :Måns Jergil; Lennart Dencker; Aldert Piersma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. LÄS MER

  3. 22. Molecular specification of expanded forebrain neural stem and progenitor cells

    Författare :Malin Parmar; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; teratology; ontogeny; embryology human ; Development biology; developmental control genes; in vitro expansion; transplantation; precursor cell; stem cells; progenitor cell; human; mouse; Utvecklingsbiologi; teratologi; embryologi människa ;

    Sammanfattning : The molecular specification of neural precursor cells has been suggested to be a progressive process, with a transition from an early requirement for extrinsic signals to intrinsic mechanisms. Thus, the cells in the nervous system acquire distinct fates in response to extrinsic signals, which activate repertoires of transcription factors in a region and cell type specific manner. LÄS MER

  4. 23. Human neural stem cells: region-specific properties and prospects for cell therapy

    Författare :Therese Kallur; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pax6; fetal cortex and striatum; human; neural stem cells; transplantation; neurospheres; stroke; overexpression; region-specific properties;

    Sammanfattning : Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. LÄS MER

  5. 24. Microenvironmental regulation of neural stem cell differentiation

    Författare :Esra Karaca; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The central nervous system consists of complex networks of neurons and other specialized cells that process information from within and outside the organism to create an output. The development of this complex machinery requires spatio-temporal regulation of neural stem cell (NSC) differentiation into the right type of cells at the right time. LÄS MER

  7. 25. The beneficial Effects of Neural Crest Stem Cells on Pancreatic      β–cells

    Författare :Anongnad Ngamjariyawat; Elena Kozlova; Leif Jansson; Jens Nielsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural Crest Stem Cells; Pancreatic Islets; β-cell proliferation; β-cell survival; Cadherin; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Patients with type-1 diabetes lose their β-cells after autoimmune attack. Islet transplantation is a co-option for curing this disease, but survival of transplanted islets is poor. Thus, methods to enhance β-cell viability and function as well as methods to expand β-cell mass are required. LÄS MER