Sökning: "neural stem"

Visar resultat 11 - 15 av 264 avhandlingar innehållade orden neural stem.

1. 11. Novel Regulators of Brain Tumor Development : – From neural stem cell differentiation to in vivo models

   Författare :Anqi Xiong; Karin Forsberg Nilsson; Joanna Phillips; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; medulloblastoma; neural stem cell; heparanase; NRBP2; dog models; susceptibility;

   Sammanfattning : Malignant brain tumors are diseases with poor prognosis and/or severe long-term side effects of treatment. This thesis aimed to discover novel regulators in brain tumor development, based on studying neural stem cell and progenitor cell (NSPC) differentiation and using animal models to introduce new insights to mechanisms of human brain tumors. LÄS MER

3. 12. Regional differences in the response of neural stem cells and their microenvironment to ionizing radiation

   Författare :Nina Hellström; Göteborgs universitet; []
   Nyckelord :ionizing radiation; neurogenesis; neural stem cells; inflammation; microglia; stem cell niche; trophic support;

   Sammanfattning : Radiation therapy is one of the most effective tools for treating malignant tumors; however, cranial irradiation often results in intellectual impairment and cognitive deficits, such as impaired learning and memory. Ionizing radiation generates DNA damage, causing proliferative cells to undergo apoptosis. LÄS MER

4. 13. Hormonal Regulation of Neural Stem Cell Proliferation and Fate Determination

   Författare :Karin Brännvall; Dan Lindholm; Sandra Ceccatelli; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Neural stem cell; Proliferation; Fate determination; Hormones; Anabolic androgenic steroids; Neurovetenskap; Neurology; Neurologi;

   Sammanfattning : Stem cells have the capacity for both self renewal, and to form all cell types in the body. Interestingly, so called neural stem cells (NSCs) are found in the adult human brain, which is of significance both out of a developmental perspective and from a clinical point of view. LÄS MER

5. 14. Adult Neural Stem Cells-Influence of Stroke, Inflammation and Aging

   Författare :Henrik Ahlenius; Lund Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; Neural stem cells; adult; neurogenesis; stroke; aging; TNF-R1; TNF-α;

   Sammanfattning : Neural stem cells (NSCs) in the embryo generate neurons, astrocytes and oligodendrocytes, the principal cells of the central nervous system (CNS), which contribute to the full diversity of the brain. Some NSCs persist in the adult brain and ensures neurogenesis throughout adult life in the subventricular zone (SVZ) and the subgranular zone (SGZ). LÄS MER

7. 15. Visualization and manipulation of microRNA in neural cells

   Författare :Rohit Sachdeva; Molekylär neurogenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microRNA; miRNA; miR-124; miR-9; embryonic stem cells; neural stem cell; cell transplantation; neurogenesis; microglia;

   Sammanfattning : microRNA (miRNA) are small non-coding RNA, 21-23 nucleotides long. miRNA provide a new layer of regulatory control over gene expression programs. It is increasingly evident that miRNA are cell type and tissue specific. Many miRNAs have been identified to be highly abundant in certain regions of the brain. LÄS MER