Sökning: "neural specification"

Visar resultat 6 - 10 av 50 avhandlingar innehållade orden neural specification.

  1. 6. Specification and potency of human neural stem cells for clinical transplantation

    Författare :Per Henrik Vincent; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neural stem cells hold promise for future treatment of spinal cord injury. Various aspects regarding cell fate specification, manufacturing and monitoring, with implications for clinical applications of these cells, are discussed herein. LÄS MER

  3. 7. Generation of cells for cell-replacement therapy: Specification of neural precursors in vivo and in neural stem cell cultures

    Författare :Josephine Hebsgaard; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurospheres; Dopaminergic neurons; Parkinson s disease; Neurogenin2;

    Sammanfattning : Cell replacement therapy of neurodegenerative disorders aims to substitute the degenerating cells with new functional neurons. Clinical trails with patients suffering from Parkinson’s or Huntington’s disease have generated proof-of-principle results that neural precursors taken from the developing human brain can survive upon grafting to the diseased brain and provide long-lasting symptomatic relief. LÄS MER

  4. 8. Phenotypic Specification of Striatal Progenitors; Evidence for both cell-autonomous and environmental control as studied by transplantation into the adult and developing rodent brain

    Författare :Martin Olsson; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; striatal projection neurons; striatal development; somatostatin; parvalbumin; neuronal differentiation; neural transplantation; medial ganglionic eminence; lateral ganglionic eminence; forebrain dvelopment; cholinergic; embryonic; thyroid transcription fa; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The striatum is the major component of the ventral telencephalon and basal ganglia, involved in the processing of cortical information. The vast majority of the neuronal population in the striatum are striatal projection neurons, with connection to the globus pallidus and substantia nigra. LÄS MER

  5. 9. Spatial and temporal regulation of neural stem cells in the developing brain by PRDM16

    Författare :Li He; Qi Dai; Christos Samakovlis; Simon Hippenmeyer; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain development; Neural stem cell; PRDM16; BMP signaling; Choroid plexus; Cortical neurogenesis; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The mammalian brain comprises a large number and diversity of neurons and non-neural cells. Most of these cell types derive from a single sheet of neuroepithelium (NE) that contains a limited pool of neural stem cells (NSCs).  NSCs in the developing brain are under complex regulation to achieve maximum daughter cell type diversity. LÄS MER

  7. 10. Early development of the olfactory placode and early rostrocaudal patterning of the caudal neural tube

    Författare :Esther Maier; Lena Gunhaga; Fernando Giraldez; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; olfactory placode; caudal neural tube; Wnt; FGF; RA; BMP; Notch; patterning; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The development of the nervous system is a complex process. Cell divisions, cell differentiation and signalling interactions must be tightly regulated. To comprehend the mature nervous system, we have to understand its assembly during development. LÄS MER