Sökning: "neural crest"

Visar resultat 11 - 15 av 71 avhandlingar innehållade orden neural crest.

  1. 11. From 1p3 to PI3K - Studies of neuroblastoma

    Författare :Susanne Fransson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; neuroblastoma; PI3K; PIK3CD; 1p36; alternative splicing; tumor; neural crest; mucosa; premalignant; tumor suppressor gene; oncogene; gene expression; epigenetics; splicing; signaling; akt; western blot; TaqMan; PIK3R1; p110H; p37H; p85; RAS;

    Sammanfattning : Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is still fatal for patients with aggressive NB and side-effects of treatment are severe. LÄS MER

  3. 12. MOLECULAR AND GENETIC STUDIES OF DLG2 IN NEUROBLASTOMA AND COLORECTAL CANCER

    Författare :Simon Keane; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Neural crest; Neuroblastoma; colon cancer; DLG2; MYCN; LIN7A; inflammation;

    Sammanfattning : Neuroblastoma is one of the most common extra cranial solid tumors in children. It is one of the most common causes of death amongst the pediatric malignancies. LÄS MER

  4. 13. Molecular and genetic studies in high-risk neuroblastoma

    Författare :Angela Martinez-Monleon; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; neural crest; neuroblastoma; heterogeneity; relapse; sequencing; CNVs; SVs; SNVs; LSAMP; CDK4; MDM2;

    Sammanfattning : Neuroblastoma is the most common and deadly cancer in the first year of life. Children with high-risk neuroblastoma have a very poor prognosis, despite heavy multimodal treatment, with less than 50% of 5 years of overall survival. LÄS MER

  5. 14. Neural progenitors for sensory and motor repair

    Författare :Jan Hoeber; Elena Kozlova; Linda Greensmith; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Regenerative Neurobiology; Stem cells; Sensory regeneration; Spinal cord injury; Amyotrophic Lateral Sclerosis; Neurodegeneration; Oxidative Stress; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Injury and neurodegenerative conditions of the spinal cord can lead to paralysis and loss of sensation. Cell therapeutic approaches can restore sensory innervation of the spinal cord following injury and protect spinal cord cells from degeneration. LÄS MER

  7. 15. Congenital malformations in experimental diabetic pregnancy : Aetiology and antioxidative treatment

    Författare :Martin Simán; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pregnancy; teratology; malformations; embryo; fetus; cataract; sorbitol; antioxidants; butylated hydroxytoluene; vitamin E; vitamin C; TBARS; neural crest cells; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Diabetes mellitus in pregnancy causes congenital malformations in the offspring.The aim of this work was to characterize biochemical and morphologic anomaliesin the conceptus of an animal model of diabetic pregnancy. In addition, apreventive treatment against diabetes-induced dysmorphogenesis was developed. LÄS MER