Sökning: "neointima"

Visar resultat 6 - 10 av 22 avhandlingar innehållade ordet neointima.

1. 6. Role of NFAT (nuclear factor of activated T cells) in vascular smooth muscle

   Författare :Lisa Berglund; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vascular smooth muscle; proliferation; A-285222; osteopontin; AIF-1; diabetes; vascular disease; calcium; glucose; NFAT;

   Sammanfattning : The calcium-dependent transcription factor NFAT was first described as a key player in immune cell regulation. Since then, NFAT signaling has been shown to be crucial for normal vascular development during embryogenesis. LÄS MER

3. 7. The vascular response to oxidative and mechanical stress

   Författare :Federico Ben Calara; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :atherosclerosis; inflammation; smooth muscle cells; low density lipoprotein; oxidized low density lipoprotein; lipid peroxidation; antioxidants; HDL; caveolae; phenotype modulation; balloon injury; immunization; growth factors;

   Sammanfattning : Atherosclerosis is a chronic inflammatory disease, which is one of leading causes of death in the Western world. The study of the vascular response to initiators of inflammation can lead us to a better understanding of the basic mechanisms that lead to the development of this disease. Balloon injured arteries develop a neointima. LÄS MER

4. 8. On cardiovascular complications in people with type 2 diabetes : Aspects of incretin-based therapy and glycemic control

   Författare :Irene Santos Pardo; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: Hyperglycemia, insulin resistance, and the presence of advanced glycation end products are key features of type 2 diabetes (T2DM) and the leading mechanisms behind the increased cardiovascular risk observed in people with this condition. Percutaneous coronary revascularization has been associated with higher risk of stent failure in people with diabetes mellitus (DM), having greater risk of both in-stent restenosis (ISR) and stent thrombosis (ST). LÄS MER

5. 9. Protective Immunity in Atherosclerosis

   Författare :Maria Wigren; Kardiovaskulär forskning - immunitet och ateroskleros; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AtherosclerosisVaccineInflammationT cellsregulatory T cells;

   Sammanfattning : The immune system is a promising target for novel therapies that are aiming at reducing cardiovascular diseases. Autoimmune responses against modified low density lipoprotein (LDL) are believed to promote development of atherosclerosis. Proinflammatory immune responses can be counterbalanced by immunosuppressive regulatory T cells (Tregs). LÄS MER

7. 10. Mechanisms and treatment options of chronic graft dysfunction : Experimental and clinical studies

   Författare :Lilija Zezina; Uppsala universitet; []
   Nyckelord :Medical sciences; chronic graft dysfunction; kidney transplantation; aorta transplantation; lipid oxidation; LDL; TGF-beta; Smad2; angiotensin II receptor; treatment; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : Chronic graft dysfunction (CGD) is an important post-transplant complication. CGD can be considered as an impaired repair process, which ultimately leads to the loss of graft function.To study non-immunological factors contributing to the development of CGD in kidney grafts we used in vitro and in vivo models, and clinical studies. LÄS MER