Sökning: "ncRNAs"

Visar resultat 16 - 20 av 23 avhandlingar innehållade ordet ncRNAs.

  1. 16. The deep evolutionary roots of non-coding RNA - a comparative genomics approach

    Författare :Marc Patrick Hoeppner; Anthony M. Poole; Britt-Marie Sjöberg; Jürgen Brosius; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-coding RNA; evolution; comparative genomics; RNA world; introns; snoRNA; miRNA; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Non-coding RNAs (ncRNA) are a diverse group of genes that do not encode proteins but function exclusively on the level of RNA and were originally suggested to be remnants of a pre-DNA stage of life known as the RNA world. More recent work, however, has uncovered a rich repertoire of previously unknown families with possible consequences for our understanding of the origin and evolution of the modern RNA infrastructure. LÄS MER

  3. 17. Deciphering the complexity of psoriasis : non-coding RNAs and cellular interactions

    Författare :Longlong Luo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Psoriasis is a prevalent immune-mediated skin disorder marked by chronically relapsing inflammation and epidermal hyperproliferation. As researchers delve deeper into the molecular intricacies of psoriasis, emerging evidence hints at the roles of non-coding RNAs (ncRNAs). LÄS MER

  4. 18. Evolution of protein and non-coding RNA genes studied with comparative genomics

    Författare :Marcela Davila Lopez; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioinformatics; evolution; non-coding RNA; gene prediction; gene order; bidirectional promoter; homologue prediction; secondary structure; RNAse P; RNase MRP;

    Sammanfattning : The identification of protein and non-coding RNA (ncRNA) genes is one important step in the analysis of a genome. This thesis focuses on the identification and analysis of proteins and ncRNAs homologues by exploiting a variety of computational methods in order to reach conclusions as to their structure, function, evolution and regulation. LÄS MER

  5. 19. On diverse biophysical aspects of genetics : from the action of regulators to the characterization of transcripts

    Författare :Aymeric Fouquier D´Hérouel; Erik Aurell; Felix Ritort; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transcription regulation; regulatory motifs; binding affinity; genetic interactions; secondary structure; sequence repeats; transcript characterization; Biological physics; Biologisk fysik;

    Sammanfattning : Genetics is among the most rewarding fields of biology for the theoretically inclined, offering both room and need for modeling approaches in the light of an abundance of experimental data of different kinds. Many aspects of the field are today understood in terms of physical and chemical models, joined by information theoretical descriptions. LÄS MER

  7. 20. The odyssey of MYC transcript from the nucleus to the cytoplasm : the molecular mechanism of the gene gating in human cancer cells

    Författare :Mirco Martino; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pathological expression of the MYC oncogene is a common denominator in a wide range of cancers and is linked with abnormal cell proliferation. To achieve this status, the MYC gene benefits from being embedded in a region rich in enhancers and super-enhancers that are often absent in the normal cell counterparts. LÄS MER