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Visar resultat 1 - 5 av 23 avhandlingar som matchar ovanstående sökkriterier.

1. 1. RNA-mediated virulence gene regulation in the human pathogen Listeria monocytogenes

   Författare :Edmund Loh; Jörgen Johansson; Nancy Freitag; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Listeria monocytogenes; virulence; ncRNAs; PrfA; 5´-UTRs; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : The Gram-positive human pathogen Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. The majority of its virulence genes are encoded on a 9-kb pathogenicity island and are controlled by the transcriptional activator PrfA. LÄS MER

3. 2. Non-coding RNAs in beta cell insulin secretion - emerging players in Type 2 Diabetes pathogenesis

   Författare :Jones Ofori; Diabetes - öcellsexocytos; []
   Nyckelord :T2D; insulin secretion; exocytosis; ncRNAs; GAS5; miR-152; miR-335; miR-130a b; miR-375; STXBP1; SNAP25; SYT13; PDHA1; PDX1; glucocortiocoid; beta cell function; glucose metabolism;

   Sammanfattning : Type 2 diabetes (T2D) is a complex polygenic disease influenced by both environmental and genetic factors resulting in impaired insulin release from pancreatic beta cells and insulin resistance in target tissues. The incidence of T2D is escalating and it is projected that over 640 million people will be affected by 2040. LÄS MER

4. 3. Ancient roles of non-coding RNAs in eukaryotic evolution : contributions from social amoebae and other protists

   Författare :Lotta Avesson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : RNAs not coding for proteins, non-coding RNAs (ncRNAs) have many important roles in all kingdoms of life. Especially in eukaryotes, the regulatory functions of ncRNAs have been suggested as a major force in the evolution of complex traits. LÄS MER

5. 4. Computational Approaches to the Identification and Characterization of Non-Coding RNA Genes

   Författare :Pontus Larsson; Anders Virtanen; Leif Kirsebom; Stephen Mount; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; Dictyostelium; nucleotide composition; partial sums; Bioinformatics; Bioinformatik;

   Sammanfattning : Non-coding RNAs (ncRNAs) have emerged as highly diverse and powerful key players in the cell, the range of capabilities spanning from catalyzing essential processes in all living organisms, e.g. protein synthesis, to being highly specific regulators of gene expression. LÄS MER

7. 5. Function and Evolution of Small Regulatory RNAs and their Associated Proteins : A Journey from Genome to Proteome

   Författare :Bart Edelbroek; Fredrik Söderbom; Jonathan R. Chubb; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microRNAs; non-coding RNAs; Evolution; Whole Genome Sequencing; Transcriptomics; Proteomics; small RNAseq; Amoebozoa; Multicellular development; Social amoebae; Comparative genomics; Genome annotation; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : Organisms throughout the tree of life have evolved distinct ways to regulate gene expression. Some of these processes involve non-coding RNAs (ncRNAs), which are not translated but functional nonetheless. These ncRNAs are of utmost importance, with dysregulation of some causing severe developmental effects or even being lethal. LÄS MER