Sökning: "natural mutations"

Visar resultat 11 - 15 av 445 avhandlingar innehållade orden natural mutations.

  1. 11. Determinants of peptidyl-tRNA drop-off from E. coli Ribosomes : Effects of antibiotics, mutations and translation factors

    Författare :Reza Karimi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : During protein synthesis, some peptidyl-tRNA molecules dissociate from the ribosomes and become hydrolysed by peptidyl-tRNA hydrolase (Pth). Two different in vitro systems, poly(U) and natural mRNA programmed ribosomes, have been used in order to determine dissociation (drop-off) rates of deacylated- and peptidyl-tRNAs from different sites on ribosomes. LÄS MER

  3. 12. Statistical assessment of somatic mutations and genomic variability using DNA sequence data

    Författare :Anna Rehammar; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA sequence data; exome sequencing; calling of somatic mutations; metagenomics; hierarchical Bayesian model; genomic variability; calling of somatic mutations;

    Sammanfattning : The development of new DNA sequencing techniques have made it possible to generate high-resolution genomic data at an unprecedented pace. However, the high dimensionality in combination with the substantial levels of technical errors and biological variability make the analysis challenging. LÄS MER

  4. 13. Genetic variation in natural populations: a modeller's perspective

    Författare :Marina Rafajlovic; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; coalescent process; site frequency spectrum; multiple paternity; dominant clone; divergent selection;

    Sammanfattning : Thanks to advances in genome sequencing, empirical patterns of within- and between-species genetic variation are readily available. By studying these patterns much has been learned about the evolutionary histories of species. But the causes and consequences of different evolutionary histories are still difficult to tell apart. LÄS MER

  5. 14. Statistical assessment of genomic variability in tumours and bacterial communities

    Författare :Anna Rehammar; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; somatic mutations; hierarchical Bayesian modelling; cancer genetics; high-throughput sequencing; metagenomics; personalised diagnostics;

    Sammanfattning : Current high-throughput DNA sequencing technologies have the ability to generate large amounts of high-resolution genomic data. The high dimensionality in combination with the substantial levels of technical errors and biological variability typically present in the data make, however, the analysis challenging. LÄS MER

  7. 15. Artificial neural networks in models of specialization and sympatric speciation

    Författare :Niclas Norrström; Högskolan i Skövde; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Naturvetenskap; Natural sciences;

    Sammanfattning : This thesis deals with specialization and how it is linked to sympatric speciation. The trait driving specialization is a cue recognition trait modelled with artificial neural networks that exploiters use to discriminate beneficial resources from detrimental resources based on the signals of the resources. LÄS MER