Sökning: "nasal tolerance"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden nasal tolerance.

  1. 1. Genetic Factors and Nasal Tolerance in Rat Models for Rheumatoid Arthritis

    Författare :Shemin Lu; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nasal tolerance; linkage analysis; MHC; genetics; pristane induced arthritis; rheumatoid arthritis; collagen induced arthritis; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : We used three animal models of rats for rheumatoid arthritis (RA) in this study. Firstly, We found that CXI induced arthritis (CXIIA) is associated with the RT1 f haplotype and follows a chronic disease course affecting peripheral joints with both progression and relapses. LÄS MER

  3. 2. Immunopathogenesis and nasal tolerance in experimental autoimmune myasthenia gravis

    Författare :Fu-Dong Shi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Myasthenia gravis (MG) is a classical antibody-mediated autoimmune disease of the neuromuscular junction. Experimental autoimmune myasthenia gravis (EAMG), can be induced in susceptible rat or mouse strains by immunization with acetylcholine receptor (AChR) in complete Freund's adjuvant (CFA). LÄS MER

  4. 3. Modulation of experimental T cell autoimmunity in the nervous system with emphasis on nasal tolerance

    Författare :Xue-Feng Bai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Experimental autoimmune neuritis (EAN) and encephalomyelitis (EAE) are animal models of Guillian-Barre syndrome (GBS) and multiple sclerosis (MS), representing human demyelinating diseases of the peripheral nervous system (PNS) and central nervous system (CNS), respectively. CD4+ T cells recognizing myelin antigens and producing cytokines play central roles in the pathogenesis of both EAN and EAE and perhaps of GBS and MS. LÄS MER

  5. 4. Allergic rhinitis and intralymphatic vaccination : immune response and tolerance

    Författare :Eric Hjalmarsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The overall goal of this thesis was to study novel immunological mechanisms for the development of pollen-induced allergic rhinitis (AR) and to evaluate the clinical response in combination with immunological changes in AR patients treated with intralymphatic immunotherapy (ILIT). In paper I, an increased fraction of neutrophils were detected in the nasal mucosa of AR patients compared with healthy controls. LÄS MER

  7. 5. T lymphocytes and cytokines in the pathogenesis of experimental autoimmune myasthenia gravis

    Författare :Guang-Xian Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Experimental autoimmune myasthenia gravis (EAMG), induced in different animal species and strains by immunization with nicotinic acetylcholine receptor (AChR) and complete Freund's adjuvant (CFA), represents an experimental model of myasthenia gravis (MG) in humans. Both MG and EAMG are autoimmune diseases mediated by antibodies against AChR of neuromuscular junctions. LÄS MER