Sökning: "naltrexone"

Visar resultat 11 - 14 av 14 avhandlingar innehållade ordet naltrexone.

  1. 11. Neuropeptides in bone and joint tissues : alteration in adjuvant arthitis

    Författare :Adlan Mahmoud Elhassan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis, the localization, distribution and quantification of met-enkephalin (Met-enk), neurokinin-A and somatostatin in normal bone and joint tissues of the rat have been studied. Moreover, concentration alterations of these neuropeptides at the site of inflammation in the arthritic ankle joints as well as the spinal cords were evaluated. LÄS MER

  3. 12. Neurochemical and behavioral studies on ethanol and brain opiod interactions in the brain

    Författare :Sara Lindholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Substance dependence is a devastating disorder that produces enormous socio-economic costs, personal tragedies and health related problems. The brain mesolimbic dopamine pathway originating in the ventral tegmental area (VTA) with projections to limbic brain structures such as the nucleus accumbens has been implicated in the reinforcing effects of different drugs of abuse. LÄS MER

  4. 13. On natural and drug-induced reward : genetic, biochemical and behavioral comparisons

    Författare :Martin Werme; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :VTA; nucleus accumbens; wheel running; exercise; drugs of abuse; addiction; compulsive; deltaFosB; Nurr1; Dynorphin;

    Sammanfattning : Work in this thesis compares natural and drug- induced reward at genetic, biochemical and behavioral levels with the objective to obtain information about key mechanisms underlying reward and addiction, and improve the understanding of compulsive elements that characterize addiction. Surveys among committed human runners have described running as addictive. LÄS MER

  5. 14. Factors affecting alcohol self-administration : learning, environmental and genetic influences on behaviour

    Författare :Christopher Pickering; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ethanol; operant self-administration; addiction; reward; learning; lever press response; context; environmental cue; novelty; stress; glutamate; GABA; noradrenaline; PCR; gene expression; functional genomics; prefrontal cortex; hippocampus; amygdala;

    Sammanfattning : Alcoholism is a serious problem for society and is a very difficult disease to treat clinically. Often, the addict has periods of abstinence from alcohol followed by relapse to drinking and this cycle of use/non-use can repeat over many years. LÄS MER