Sökning: "myosin heavy chains"

Hittade 5 avhandlingar innehållade orden myosin heavy chains.

  1. 1. Human extraocular muscles : molecular diversity of a unique muscle allotype

    Författare :Daniel Kjellgren; Fatima Pedrosa-Domellöf; Lars-Erik Thornell; Lillemor Wachtmeister; John Porter; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ophtalmology; extraocular; muscle; myosin; protein c; laminin; serca; immunocytochemistry; human; Oftalmiatrik; Ophtalmology; Oftalmologi; oftalmiatrik; Ophtalmology;

    Sammanfattning : Introduction: The extraocular muscles (EOMs) are considered a separate class of skeletal muscle, allotype. Myosin is the major contractile protein in muscle. The myosin heavy chain (MyHC) isoforms are the best molecular markers of functional heterogeneity of muscle fibers. LÄS MER

  3. 2. A novel single skeletal muscle cell in vitro motility assay : effects of aging and non-enzymatic glycosylation on myosin function

    Författare :Peter Höök; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :In vitro motility; motility speed; aging; single muscle fiber; myosin isoform; temperature; scaling; glycation;

    Sammanfattning : The aims of this study were to develop a single skeletal muscle fiber in vitro motility assay, and to employ the assay in order to study the effects of aging and non-enzymatic glycosylation on the mechanical properties of the motor protein myosin in an attempt to improve our understanding of the molecular mechanisms underlying the aging-related impairment in regulation of muscle function. Myosin was extracted from a millimeter short single muscle fiber segment directly onto a nitrocellulosecoated coverslip for subsequent analyses of the functional properties of the motor protein. LÄS MER

  4. 3. Effects of unloading and resistance exercise on skeletal muscle function, size and composition in man

    Författare :Björn Alkner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atrophy; bed rest; confinement; countermeasure; electromyography; human; knee extensors; magnetic resonance imaging; microgravity; muscle function; myosin heavy chains; plantar flexors; resistance exercise; skeletal muscle; spaceflight; strength; training specificity; unloading;

    Sammanfattning : Exposure to microgravity, i.e., spaceflight, causes muscle unloading leading to muscle atrophy and dysfunction. Thus, there is a need for effective countermeasures to combat these effects. LÄS MER

  5. 4. Morphological and electromyographical studies of trapezius myalgia in cleaners

    Författare :Britt Larsson; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; female cleaners; Trapezius myalgia; work-related; arbetsmiljömedicin; Yrkesmedicin; industrial medicine; Occupational health; morphological analysis and surface-EMG;

    Sammanfattning : Pathomechanisms of work-related myalgia are poorly understood. Myalgia is caused by exitation of nociceptors present in the muscular tissue but not in the muscle fibres themselves. Morphological analysis can contribute to knowledge of excitation of nociceptors. Surface EMG is a widely used method in the research field of ergonomics. LÄS MER

  7. 5. Gene expression profiles at the myotonic dystrophy 1 locus : possible role in disease mechanisms

    Författare :Maria Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Myotonic dystrophy 1 (DM1) is the commonest adult onset muscular dystrophy, (prevalence 1/8000). The disorder is characterized by anticipation (earlier onset in successive generations, which is accompanied in this disorder by an increase in severity of symptoms) and variable multisystemic symptom presentation. LÄS MER