Sökning: "myocardium"

Visar resultat 16 - 20 av 115 avhandlingar innehållade ordet myocardium.

  1. 16. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

    Författare :Aliaksandr Bulhak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

    Sammanfattning : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. LÄS MER

  3. 17. Assessment of Myocardial Perfusion with Magnetic Resonance Imaging and an Intravascular Contrast Agent

    Författare :Tomas Bjerner; Christine Lorenz; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Magnetic resonance imaging; Intravascular contrast agents; Myocardial perfusion; Onkologi; Oncology; Onkologi; radiologi; Radiology;

    Sammanfattning : The intravascular contrast agent NC100150 Injection (Clariscan™) was tested for its ability to induce signal intensity changes in myocardium, both in steady state and during first pass, and thereby demarcating non-perfused myocardium from perfused. Steady state: Ex vivo in pigs and when using 4 mg Fe/kg bodyweight (b.w. LÄS MER

  4. 18. Cell transplantation with human mesenchymal or embryonic stem cells to the heart : experimental, molecular, immunological and echocardiographic studies

    Författare :Karl-Henrik Grinnemo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human mesenchymal stem cells; human embryonic stem cells; human cardiomyocyte; Islet-1; Nkx2.5; stem cell; xenotransplantation; rejection; FoxP3 T-cells; tolerance; CTLA4Ig; anti- CD40L; LFA-1;

    Sammanfattning : Background: Human mesenchymal stem cells (hMSC), human embryonic stem cells (HESC) and human fetal cardiomyocyte progenitor cells (HFCP) all represent possible candidate cells for regeneration of damaged myocardium. Although they represent cell types with many positive attributes, their capacity to engraft, to differentiate into mature cardiomyocytes, to improve myocardial function and their immunological properties are the focus of these studies. LÄS MER

  5. 19. Kinematics of the heart : strain and strain-rate using time-resolved three-dimensional phase contrast MRI

    Författare :Pernilla Selskog; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : During the cardiac cycle, the myocardium (heart muscle) undergoes large elastic deformations as a consequence of the active muscle contraction along the muscle :fibers and their relaxation, respectively. A four-dimensional (4D) description (three spatial dimensions + time) of the kinematics of the myocardium would bring increased understanding of the mechanical properties of the heart and may be of interest in assessing regional myocardial function. LÄS MER

  7. 20. Modelling of strain tensors in cardiac kinematics

    Författare :Katarina Kindberg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The heart wall consists of three distinct layers: the inner endocardium, the middle myocardium and the outer epicardium. The myocardium is the functional tissue that endows the heart with its ability to pump blood, and consists primarily of locally parallel muscle fibers. The orientation of these muscle fibers change with position in the wall. LÄS MER