Sökning: "myelopoiesis"

Visar resultat 6 - 10 av 10 avhandlingar innehållade ordet myelopoiesis.

  1. 6. FLT3 receptor in normal and malignant hematopoiesis

    Författare :Shabnam Kharazi; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FLT3-ITD; FLT3; lineage commitment; acute myeloid leukemia; myeloprolifetaive disease; hematopoietic stem cell;

    Sammanfattning : All hematopoietic cells originate from hematopoietic stem cells (HSCs) residing in the bone marrow (BM). The classical model of hematopoietic lineage commitment, that has been the prevailing model for hematopoiesis, proposes that the first lineage commitment step of HSCs and progenitors results in a strict separation of myelopoiesis and lymphopoiesis. LÄS MER

  3. 7. Epigenetic regulation of transcription and cellular development

    Författare :Farzaneh Shahin Varnoosfaderani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epigenetic machinery can regulate different biological processes via different mechanisms. In this thesis, we explore the effects of the epigenetic system on transcription and how it can differ during cellular development in different human cell lines models, with focus on hematopoiesis. LÄS MER

  4. 8. Molecular Genetic Studies of ALSG, Kostmann Syndrome and a Novel Chromosome 10 Inversion

    Författare :Miriam Entesarian; Niklas Dahl; Niels Tommerup; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; Klinisk genetik; Clinical Genetics; klinisk genetik;

    Sammanfattning : In summary, this thesis presents the localisation and identification of genetic variants of which some are disease associated and some considered to be neutral. Knowledge of the basic mechanisms behind human disorders is important both from a biological and medical point of view. LÄS MER

  5. 9. Hematopoiesis: Functional Insights by Cell Fate Conversion

    Författare :Martin Wahlestedt; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Blood cell formation, or hematopoiesis, is maintained by rare hematopoietic stem cells (HSCs) residing in the bone marrow (BM). HSCs may self-renew (the process whereby HSCs replicate to produce new HSCs) to preserve their own numbers, as well as initiate a highly coordinated hierarchical differentiation process that results in the production of mature effector blood cells. LÄS MER

  7. 10. Kostmann syndrome : a clinical and pathophysiological study

    Författare :Göran Carlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Kostmann syndrome; severe congenital neutropenia; autosomal recessive; periodontitis; antibacterial peptides; LL-3 7; apoptosis; Bcl-2; granulocyte colony-stimulating factor; glycosylation; lenograstim; filgrastim.;

    Sammanfattning : Kostmann syndrome or severe congenital neutropenia (SCN) is a rare disease, usually diagnosed during the first months of life, characterized by extremely low levels of neutrophils in the peripheral blood, a maturational arrest of the myelopoiesis in the bone marrow and severe bacterial infections. The purpose of this project was to improve the understanding of the clinical course and the pathophysiology of autosomal recessive SCN. LÄS MER