Sökning: "myelopoiesis"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet myelopoiesis.

1. 1. Studies of leukotriene C4 synthase expression and regulation in chronic myeloid leukaemia

   Författare :Cecilia Roos; Susanne Tornhamre; Anita Sjölander; Karlstads universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; leukotriene C4 synthase; chronic myeloid leukaemia; p210 BCR-ABL; myelopoiesis; imatinib mesylate; Cell biology; Cellbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

   Sammanfattning : Leukotriene (LT) C4 is generated through conjugation of LTA4 with glutathione by the actions of leukotriene C4 synthase (LTC4S). This biologically potent mediator of asthma and inflammation has also been suggested to play a regulatory role in human myelopoiesis and is overproduced by blood and bone marrow cells from patients with chronic myeloid leukaemia (CML). LÄS MER

3. 2. Bactericidal/Permeability-Increasing Protein (BPI) and Proteinase 3: Studies at the Transcriptional Level

   Författare :Katrien Pieters; Avdelningen för hematologi och transfusionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; azurophil granules; myelopoiesis; BPI; mouse ortholog; proteinase 3; transcriptional regulation; Wegener s Granulomatosis WG ; SNP; Medicine human and vertebrates ; extracellulära vätskor; Hematologi; extracellular fluids; Haematology; Medicin människa och djur ;

   Sammanfattning : In myelopoiesis, neutrophils and monocytes/macrophages are formed from a common myeloid precursor cell in the bone marow. During maturation of neutrophils, cytoplasmic granules are formed in the cells and the content of these granules is critical for the function of neutrophils in the first line of defense against invading microorganisms. LÄS MER

4. 3. The Road to Maturity - Lineage Commitment in early Hematopoiesis

   Författare :Charlotta Böiers; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The road to maturity – how do hematopoietic stem cells (HSC) differentiate into mature blood cells? The pathways of lineage commitment during normal hematopoiesis are of great significance in order to understand the underlying events that lead to leukemia, and to the design of proper treatments for prevention and remission of the disease. The route of hematopoiesis can be thought of as a hierarchical tree, with the rare HSCs at the top, transitioning down along the pathways as different progenitors. LÄS MER

5. 4. Vitamin D, bone turnover markers and hCAP-18 in children with hemato-oncological diseases

   Författare :Natalja Jackmann; Per Frisk; Outi Mäkitie; Jan Gustafsson; Anna Sällfors Holmqvist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vitamin D; pediatric cancer; leukemia; bone marrow failure; hCAP-18; bone turnover markers; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Children with hemato-oncological diseases may have significant skeletal morbidities. Vitamin D is essential for the maintenance of skeletal health and may also be important for immunological functions and cancer outcomes. LÄS MER

7. 5. Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis

   Författare :Natalija Buza-Vidas; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; Haematology; Medicin människa och djur ; Medicine human and vertebrates ; lineage commitment; cytokines; lymphopoiesis; extracellulära vätskor; transplantation; hematopoietic stem cells;

   Sammanfattning : Large numbers of blood cells need to be continuously replaced in order to sustain the crucial functions of the immune system, oxygen transport and blood clotting. The large diversity of cell types required to maintain the integrity of the blood system are all produced from blood forming or hematopoietic stem cells (HSCs). LÄS MER