Sökning: "myelopoiesis"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet myelopoiesis.

  1. 1. Studies of leukotriene C4 synthase expression and regulation in chronic myeloid leukaemia

    Detta är en avhandling från Karlstad : Karlstads universitet

    Författare :Cecilia Roos; Karlstads universitet.; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; leukotriene C4 synthase; chronic myeloid leukaemia; p210 BCR-ABL; myelopoiesis; imatinib mesylate; NATURAL SCIENCES Biology Cell and molecular biology Cell biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Cellbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Leukotriene (LT) C4 is generated through conjugation of LTA4 with glutathione by the actions of leukotriene C4 synthase (LTC4S). This biologically potent mediator of asthma and inflammation has also been suggested to play a regulatory role in human myelopoiesis and is overproduced by blood and bone marrow cells from patients with chronic myeloid leukaemia (CML). LÄS MER

  2. 2. Bactericidal/Permeability-Increasing Protein (BPI) and Proteinase 3: Studies at the Transcriptional Level

    Detta är en avhandling från Divison of Hematology and Transfusion Medicine, Lund University

    Författare :Katrien Pieters; Lund University.; Lunds universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; azurophil granules; myelopoiesis; BPI; mouse ortholog; proteinase 3; transcriptional regulation; Wegener s Granulomatosis WG ; SNP; Medicine human and vertebrates ; extracellulära vätskor; Hematologi; extracellular fluids; Haematology; Medicin människa och djur ;

    Sammanfattning : In myelopoiesis, neutrophils and monocytes/macrophages are formed from a common myeloid precursor cell in the bone marow. During maturation of neutrophils, cytoplasmic granules are formed in the cells and the content of these granules is critical for the function of neutrophils in the first line of defense against invading microorganisms. LÄS MER

  3. 3. The Road to Maturity - Lineage Commitment in early Hematopoiesis

    Detta är en avhandling från Lund Stem Cell Center

    Författare :Charlotta Böiers; Lund University.; Lunds universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The road to maturity – how do hematopoietic stem cells (HSC) differentiate into mature blood cells? The pathways of lineage commitment during normal hematopoiesis are of great significance in order to understand the underlying events that lead to leukemia, and to the design of proper treatments for prevention and remission of the disease. The route of hematopoiesis can be thought of as a hierarchical tree, with the rare HSCs at the top, transitioning down along the pathways as different progenitors. LÄS MER

  4. 4. Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis

    Detta är en avhandling från Hematopoietic Stem Cell Laboratory

    Författare :Natalija Buza-Vidas; Lund University.; Lunds universitet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; Haematology; Medicin människa och djur ; Medicine human and vertebrates ; lineage commitment; cytokines; lymphopoiesis; extracellulära vätskor; transplantation; hematopoietic stem cells;

    Sammanfattning : Large numbers of blood cells need to be continuously replaced in order to sustain the crucial functions of the immune system, oxygen transport and blood clotting. The large diversity of cell types required to maintain the integrity of the blood system are all produced from blood forming or hematopoietic stem cells (HSCs). LÄS MER

  5. 5. FLT3 receptor in normal and malignant hematopoiesis

    Detta är en avhandling från Lund Stem Cell Center, Faculty of Medicine, LU

    Författare :Shabnam Kharazi; Lund University.; Lunds universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FLT3-ITD; FLT3; lineage commitment; acute myeloid leukemia; myeloprolifetaive disease; hematopoietic stem cell;

    Sammanfattning : All hematopoietic cells originate from hematopoietic stem cells (HSCs) residing in the bone marrow (BM). The classical model of hematopoietic lineage commitment, that has been the prevailing model for hematopoiesis, proposes that the first lineage commitment step of HSCs and progenitors results in a strict separation of myelopoiesis and lymphopoiesis. LÄS MER