Sökning: "myeloid leukemia"
Visar resultat 16 - 20 av 195 avhandlingar innehållade orden myeloid leukemia.
16. Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia
Sammanfattning : Acute myeloid leukemia (AML) is a life-threatening malignant disorder with dismal prognosis. AML is characterized by frequent genetic changes involving tyrosine kinases, normally acting as important mediators in many basic cellular processes. LÄS MER
17. Receptors and Regulators of Myeloid Leukemia
Sammanfattning : .... LÄS MER
18. CRISPR Screens Identify Candidate Therapeutic Targets in Leukemia
Sammanfattning : Acute myeloid leukemia (AML) is a complex hematological malignancy marked by proliferation of immature myeloid cells with a dismal 5-year survival. A major challenge is the persistence of leukemia stem cells (LSCs) after standard treatment, leading to relapse. LÄS MER
19. Redox reactions in cancer: impact and regulation
Sammanfattning : The reduction-oxidation (redox) reaction involves a change in the oxidation state of molecules where a molecule that donates an electron is oxidized and a molecule that accepts an electron is reduced. The NADPH oxidase of myeloid cells, NOX2, is a major source of oxidants in the form of reactive oxygen species (ROS), which are short-lived oxygen derivatives. LÄS MER
20. Characterization of Genetic Abnormalities at Disease Progression of Chronic Myeloid Leukemia
Sammanfattning : Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the translocation t(9;22)(q34;q11) and progresses from a relatively indolent chronic phase (CP) to an accelerated phase (AP) and finally to the more aggressive blast crisis (BC). The general aim of this thesis was to identify and characterize genetic abnormalities occurring at disease progression of CML using molecular cytogenetic, molecular genetic, and bioinformatic analyses. LÄS MER