Sökning: "muscle wasting"

Visar resultat 21 - 25 av 29 avhandlingar innehållade orden muscle wasting.

1. 21. Glutamine kinetics in critically ill patients

   Författare :Marie Smedberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Critical illness, defined as a life-threatening organ failure, entails an extreme stress that results in a pathophysiology of its own. The abnormal metabolism of these patients causes a severe muscle wasting that is poorly understood. LÄS MER

3. 22. Mechanisms underlying metabolic alterations in Huntington's disease. Beyond the brain and back

   Författare :Elna Dickson; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington s disease; huntingtin; metabolism; hypothalamus; adipose tissue;

   Sammanfattning : Huntington’s disease is caused by a mutation in the gene that codes for the protein huntingtin (HTT). A therapeutic strategy for Huntington’s disease is to lower the levels of huntingtin in the brain. However, multiple clinical trials have been stopped due to adverse effects. LÄS MER

4. 23. Mutant superoxide dismutase-1-caused pathogenesis in amyotrophic lateral sclerosis

   Författare :Daniel Bergemalm; Stefan Marklund; Thomas Brännström; Peter Andersen; Caterina Bendotti; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; mitochondria; proteome; transgenic mice; inclusion; Clinical chemistry; Klinisk kemi; biokemi; Biochemistry; neurologi; Neurology; Clinical Chemistry; klinisk kemi; patologi; Pathology;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a devastating disease that affects people in their late mid-life, with fatal outcome usually within a few years. The progressive degeneration of neurons responsible for muscle movement (motor neurons) throughout the central nervous system (CNS) leads to muscle wasting and paralysis, and eventually affects respiratory function. LÄS MER

5. 24. Living with deteriorating and hereditary disease : experiences over ten years of persons with muscular dystrophy and their next of kin

   Författare :Katrin Boström; Gerd Ahlström; Berth Danermark; Anders Möller; Örebro universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Social sciences; muscular dystrophy; chronic disease; ten year follow up; next of kin; ICF; activity; sickness impact; hereditary aspects; illness related problems; quality of life; multimethod; content analysis; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; Disability research; Handikappsforskning; Handikappvetenskap; Disability Science;

   Sammanfattning : The overall aim of this thesis was to elucidate haw persona with muscular dystrophy (MD) and their next of kin experience and describe their daily lives over the last ten years. MD is a group of inherited disorders characterised by muscular weakness caused by muscle wasting. Both qualitative and quantitative methods were used. LÄS MER

7. 25. SOD1 prions transmit templated aggregation and fatal ALS-like disease

   Författare :Elaheh Ekhtiari Bidhendi; Thomas Brännström; Stefan L. Marklund; Peter M. Andersen; Inger Nennesmo; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; amyotrophic lateral sclerosis; SOD1; prion; neurodegeneration; strain; seeding; protein misfolding; protein aggregation; propagation; transgenic mice; Pathology; patologi; Neurology; neurologi;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is an adult-onset fatal neurodegenerative disease characterized by a progressive degeneration of the upper and lower motor neurons. The resulting paresis begins focally, usually in one muscle, and spreads contiguously, leading to muscle wasting, progressive paralysis and eventually death. LÄS MER