Sökning: "muscle wasting"

Visar resultat 16 - 20 av 29 avhandlingar innehållade orden muscle wasting.

  1. 16. Critical illness myopathy : effects of specific intervention strategies and molecular mechanisms

    Författare :Rebeca Corpeño Kalamgi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscles are a tissue with remarkable adaptability and are essential in the body in many aspects. The homeostasis of the muscles is vital for the maintenance of the body, thus muscle damage is associated with several diseases and leads to a poor quality of life. LÄS MER

  3. 17. Potential therapies and biomarkers for LAMA2-CMD. Does the microRNA hype deliver?

    Författare :Bernardo Moreira Soares Oliveira; Muskelbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muskeldystrofi; genetic-markers; Small non-coding RNAs;

    Sammanfattning : Laminin α2 chain-deficient muscular dystrophy, or LAMA2-CMD, is a very severe disease caused by mutations in the LAMA2 gene. Skeletal muscle is the most affected tissue, with patients presenting symptoms such as hypotonia at birth, joint contractures and progressive muscle wasting. LÄS MER

  4. 18. Glucocorticoids - outcome in patients with glucocorticoid deficiency and Cushing's syndrome

    Författare :Oskar Ragnarsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular risk; bone mineral density; paediatric; final height; cognitive function; fatigue; attentional network test; body composition; sarcopaenia; growth hormone;

    Sammanfattning : Glucocorticoids (GCs) are steroid hormones that have a major impact on human metabolism and are essential for life. Chronic GC overexposure, called Cushing’s syndrome, is characterized by central obesity, muscle atrophy, osteoporosis, hypertension, impaired glucose tolerance and neurocognitive impairment. LÄS MER

  5. 19. Brown is the new white: consequences of white adipose tissue alterations in Huntington's disease

    Författare :Andy Mccourt; Biomarkörer vid hjärnsjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; weight loss; white adipose tissue; brown adipose tissue; peripheral symptoms; R6 2 mice; UCP1; CREB1; gene expression;

    Sammanfattning : Huntington's disease (HD) is a devastating, inherited neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Peripheral symptoms, such as skeletal muscle wasting, progressive weight loss, altered body composition and endocrine disturbances exist alongside neurodegeneration. LÄS MER

  7. 20. Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy

    Författare :Alexander Nyström; Muskelbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vasculature; angiogenesis; Medicine human and vertebrates ; disease; LG domains; Laminin; Medicin människa och djur ;

    Sammanfattning : Basement membranes are sheet like extracellular matrices that underlie or surround many cell types. They are crucial for key cellular events such as cell migration, proliferation, survival and differentiation. Vital components of all basement membranes are laminins, heterotrimeric combinations of different laminin chain isoforms. LÄS MER