Sökning: "muscle wasting"
Visar resultat 11 - 15 av 29 avhandlingar innehållade orden muscle wasting.
11. A peripheral immune response in Huntington's disease and delineation of its importance in disease pathology
Sammanfattning : Huntington’s disease (HD) is a fatal, hereditary disease for which there is no cure. It is caused by a mutation in a gene called huntingtin. HD is a so-called neurodegenerative disease, where there is a loss of neurons in areas of the brain that control body movements. This results in uncontrolled dance-like movements (chorea). LÄS MER
12. Celluar and Molecular Mechanisms Underlying Regulation of Skeletal Muscle Contraction in Health and Disease
Sammanfattning : Morphological changes, genetic modifications, and cell functional alterations are not always parallel. Therefore, assessment of skeletal muscle function is an integral part of the etiological approach. LÄS MER
13. Novel risk markers in the chronic kidney disease patient : new insights into the wasting-inflammation axis
Sammanfattning : Patients with chronic kidney disease (CKD) have a risk of cardiovascular morbidity and mortality that is 20 ]30 fold higher than that of a similar person without CKD. While traditional (i.e Framingham) risk factors certainly contribute, they cannot by themselves explain this exacerbated mortality burden. LÄS MER
14. Congenital muscular dystrophy with laminin α2 chain-deficiency. Initiation of disease and development of treatment
Sammanfattning : Congenital muscle dystrophy type 1A (MDC1A) is a muscle disease caused bymutations in the LAMA2 gene, encoding the basement membrane protein lamininα2 chain. MDC1A patients exhibit neonatal onset of muscle weakness, progressivemuscle wasting and hypotonia, joint contractures that mostly affect elbows, hips,knees and ankles along with scoliosis and delayed motor milestones. LÄS MER
15. Critical illness myopathy : mechanisms and pharmacological interventions
Sammanfattning : The human body typically contains over 600 skeletal muscles that make up about 40% of total body weight. These muscles work together to perform functions such as locomotion, breathing, mastication, heat regulation and speech. LÄS MER