Sökning: "multivariate analysis."

Visar resultat 21 - 25 av 751 avhandlingar innehållade orden multivariate analysis..

1. 21. Raman Spectroscopy and Hyperspectral Analysis of Living Cells Exposed to Nanoparticles

   Författare :Linnea Ahlinder; Lars Österlund; Ioan Notingher; Uppsala universitet; []
   Nyckelord :Raman spectroscopy; Hyperspectral analysis; Multivariate data analysis; Nanotoxicology; Graphene oxide; Iron oxide; Titanium dioxide; Cells;

   Sammanfattning : Nanoparticles, i.e. particles with at least one dimension smaller than 100 nm, are present in large quantities in ambient air and can also be found in an increasing amount of consumer products. It is known that many nanomaterials have physicochemical properties that differ from physicochemical properties of the same material in bulk size. LÄS MER

3. 22. Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity

   Författare :Olof Modén; Bengt Mannervik; Mikael Widersten; Kenneth Tew; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; allelic variants; azathioprine; bioactivation; chimeric mutagenesis; directed evolution; DNA shuffling; enzyme engineering; glutathione transferase; GST; lysate screening; molecular docking; multiple alignment; multivariate analysis; polymorphism; principal component analysis; prodrug; prodrug activation; protein engineering; protein redesign; reduced amino acid alphabet; saturation mutagenesis; semi-rational enzyme engineering; site-directed mutagenesis; structure-activity relationship; structure-based redesign; Biokemi; Biochemistry;

   Sammanfattning : Glutathione transferase (GST) A2-2 is the human enzyme most efficient in catalyzing azathioprine activation. Structure-function relationships were sought explaining the higher catalytic efficiency compared to other alpha class GSTs. LÄS MER

4. 23. Directed Evolution of Glutathione Transferases Guided by Multivariate Data Analysis

   Författare :Sanela Kurtovic; Bengt Mannervik; Ulf Hellman; Denis Pompon; Uppsala universitet; []
   Nyckelord :Biochemistry; DNA shuffling; substrate selectivity; mutant library; glutathione transferase; multivariate data analysis; prodrug; Biokemi;

   Sammanfattning : Evolution of enzymes with novel functional properties has gained much attention in recent years. Naturally evolved enzymes are adapted to work in living cells under physiological conditions, circumstances that are not always available for industrial processes calling for novel and better catalysts. LÄS MER

5. 24. A multivariate approach to QSAR

   Författare :Sven Hellberg; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; QSAR; beta-adrenergic agents; haloalkanes; halogenated anesthetics; peptides; fractional factorial design; multivariate data analysis; principal components PC ; partial least squares PLS ;

   Sammanfattning : Quantitative structure-activity relationships (OSAR) constitute empirical analogy models connecting chemical structure and biological activity. The analogy approach to QSAR assume that the factors important in the biological system also are contained in chemical model systems.The development of a QSAR can be divided into subproblems:1. LÄS MER

7. 25. Chemical Sensors and Multivariate Data Analysis

   Författare :Henrik Petersson; Linköpings universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

   Sammanfattning : Today, sensors can be found in many different applications, such as in home appliances, vehicles, medical equipments, mobile technology etc. Nearly all products with a reasonable technological height have a sensor integrated.Chemical Sensors are devices able to sense the chemical environment and are today an active area of research. LÄS MER