Sökning: "multiprotein analysis"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden multiprotein analysis.

  1. 1. Predictive and prognostic factors in cervical carcinomas treated with (chemo-) radiotherapy

    Författare :Louise Bohr Mordhorst; Bengt Sorbe; Preben Kjölhede; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cervical carcinoma; radio-chemotherapy; biomarkers; predictive factors; prognostic factors; multiprotein analysis; Hedgehog pathway; Wnt β-catenin pathway; Surgery; Kirurgi;

    Sammanfattning : A series of 131 women with cervical carcinoma FIGO stage I-IV were treated with external radiotherapy and intracavitary brachytherapy. In 47 patients (36%) concomitant chemotherapy was given. One hundred and twenty-one tumors (92%) achieved complete remission. Addition of chemotherapy increased primary cure rate to 98%. LÄS MER

  3. 2. Proteome-wide analysis of severe bacterial infections. The battle between host and pathogen

    Författare :Anahita Bakochi; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Mass Spectrometry; Systems biology; Host adaptation; Meningitis; Streptococcus pneumoniae;

    Sammanfattning : The pathogenesis of severe infectious diseases is a complex interplay between the host and the pathogen. The development and progression of a disease encompasses a multitude of processes, which balance between host-damage and host-protection. LÄS MER

  4. 3. Molecular and ultrastructural analysis of Tpr, a nuclear pore complex-attached coiled-coil protein

    Författare :Manuela Hase; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Anchored in the nuclear envelope, nuclear pore complexes (NPCs) are large multiprotein complexes which serve as the gateway for nucleocytoplasmic transport. In vertebrates, a 267kDa protein termed Tpr has been localized to the nucleoplasmic side of the NPCs. The function of Tpr has remained largely elusive. LÄS MER

  5. 4. Structural insights into protein-protein interactions governing regulation in transcription initiation and ubiquitination

    Författare :Madhanagopal Anandapadamanaban; Maria Sunnerhagen; Martin Moche; Marie Wahren-Herlenius; Cynthia Wolberger; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Virtually every aspect of the cellular processes in eukaryotes requires that the interactions between protein molecules are well coordinated in different regulatory pathways. Any protein dysfunction involved in these regulatory pathways might lead to various pathological conditions. LÄS MER

  7. 5. Fission yeast mediator complex and its role in transcriptional regulation

    Författare :Olga Khorosjutina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mediator is an evolutionary conserved co-activator complex that regulates transcription of protein encoding genes in eukaryotes. This multiprotein complex was first identified in budding yeast and shown to be indispensable for RNA polymerase II (pol II) dependent transcription. LÄS MER