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Visar resultat 1 - 5 av 10 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Image-based multi-omics data integration : Exploring whole-body PET/MRI, -omics data and body composition

   Författare :Robin Visvanathar; Håkan Ahlström; Joel Kullberg; Jan Eriksson; Katrine Riklund; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Body composition; Imiomics; genomics; metabolomics; MRI; PET; insulin sensitivity; T2D;

   Sammanfattning : Advanced body composition analysis with whole-body imaging could uncover novel associations between regional tissue composition and metabolic disease. Imiomics is an automated image analysis framework that enables large-scale integration of magnetic resonance imaging (MRI) data and orthogonal technologies such as metabolomics and genomics for the detailed study of body composition. LÄS MER

3. 2. On metabolic networks and multi-omics integration

   Författare :Rasmus Ågren; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; succinate; genome-scale metabolic model; metabolic engineering; systems biology; penicillin; NASH; flux balance analysis; metabolism; cancer; reconstruction;

   Sammanfattning : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. LÄS MER

4. 3. The Dark side of Obesity: Multi-omics analysis of the dysmetabolic morbidities spectrum

   Författare :Dimitra Lappa; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; systems biology; Obesity; multi-omics integration; biomarkers; gallstones; non-alcoholic fatty liver disease; GPCR receptors; metabotyping; bariatric surgery; self-organizing maps;

   Sammanfattning : Obesity is one of the most prevalent clinical conditions worldwide and is associated with a wide spectrum of dysmetabolic comorbidities. Complex cardio-metabolic disease cohorts, such as obesity cohorts are characterised by population heterogeneity, multiple underlying diseases status and different comorbidities’ treatment regiments. LÄS MER

5. 4. In search of early biomarkers in pancreatic ductal adenocarcinoma using multi-omics and bioinformatics

   Författare :Emmy Borgmästars; Malin Sund; Ola Billing; Pär Jonsson; Zelmina Lubovac-Pilav; Oskar Franklin; Stefan Enroth; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Pancreatic cancer; microRNA functional analysis; TPS; miRNomics; metabolomics; proteomics; plasma samples; early detection; risk; survival;

   Sammanfattning : Background: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive malignancy with a 5-year survival of 10 %. Surgery is the only curative treatment. Unfortunately, few patients are eligible for surgery due to late detection. Thus, we need ways to detect the disease at an earlier stage and for that good screening biomarkers could be used. LÄS MER

7. 5. An integrative systems biology study to understand immune aging in people living with HIV

   Författare :Flora Mikaeloff; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Antiretroviral therapy (ART) reduces viral replication, restores T helper cells and improves the survival of people living with HIV (PWH), transforming a life-threatening disease into a manageable chronic infection. Nevertheless, PWH under ART shows aging-related diseases such as bone abnormalities, non-HIV-associated cancers, and cardiovascular and neurocognitive diseases. LÄS MER