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  1. 1. Colonic mucus structure and processing

    Författare :Elisabeth E. L. Nyström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucus; CLCA1; Goblet cell; Spdef;

    Sammanfattning : The mucus layer covering the colonic epithelium creates a crucial first line of defense against the gut residing bacteria. Several lines of evidence suggest that a functional mucus layer is essential for health. For example, it is. suggested that ulcerative colitis is correlated with mucus layer defects. LÄS MER

  3. 2. Understanding the gastrointestinal mucus and its impact on drug absorption

    Författare :Vicky Barmpatsalou; Christel Bergström; Eva Karlsson; Betty Lomstein Pedersen; Hanne Mørck Nielsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucus; gastrointestinal; pigs; dogs; physiology; colonic; in vitro assay; drug diffusion; macromolecules;

    Sammanfattning : The gastrointestinal mucus is a hydrogel lining the luminal side of the gastrointestinal epithelium. Mucus is vital for gut homeostasis because it protects the epithelium from the noxious external environment. LÄS MER

  4. 3. The MUC2 mucin -A network in the intestinal protective mucus

    Författare :Malin E V Johansson; Göteborgs universitet; []
    Nyckelord :mucus; Muc2; trimer; proteomics; intestine; colitis; DSS;

    Sammanfattning : The intestine is covered by mucus that is the first line of defence of the epithelium. The main structural component of the intestinal mucus is the MUC2 mucin. This is a large glycoprotein with two long and heavily O-glycosylated mucin domains. LÄS MER

  5. 4. The Role of FCGBP in Mucus - Structure, Processing and Function

    Författare :Erik Ehrencrona; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mucus; FCGBP; IgG; IBD; COPD; Mucins; Disulphide; GDPH;

    Sammanfattning : In this thesis, a bottom-up approach was used to study the IgG Fc-binding protein (FCGBP), which next to the MUC2 mucin is the second main component of secreted mucus in small intestine and colon. FCGBP is also found in airways during inflammatory conditions with static mucus. LÄS MER

  7. 5. Mucus associated proteins and their functional role in the distal intestine

    Författare :Joakim H. Bergström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestine; mucus; bacteria; MUC2; AGR2; FCGBP; ZG16;

    Sammanfattning : The mammalian intestine, especially the large intestine, harbors complex societies of beneficial bacteria coexisting with the host. This is a mutualistic relationship, where the host provides nutrients and a favorable environment while the bacteria in return ferment indigestible polysaccharides to short chain fatty acids. LÄS MER