Sökning: "mucosal"

Visar resultat 16 - 20 av 482 avhandlingar innehållade ordet mucosal.

  1. 16. Mucosal adjuvants and their mode of action in the female genital tract

    Författare :Madelene Lindqvist; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunology; mucosal adjuvants; genital tract; vaccine; HSV-2; mouse; alpha-galactosylceramid; CpG ODN; proteoliposome-derived cochleate; inflammation; bioinformatics;

    Sammanfattning : Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is caused by herpes simplex virus type 2 with over 536 million people infected world-wide. LÄS MER

  3. 17. Antibody responses in genital secretions and serum after mucosal vaccination in humans

    Författare :Lotta Wassén; Göteborgs universitet; []
    Nyckelord :genital immunity; antibodies; mucosal vaccination; cervical secretions; vaginal fluids;

    Sammanfattning : The overall aim of this thesis was to study the induction of B-cell immune responses in genital secretion and serum after mucosal vaccination in women. Oral inactivated B subunit whole-cell (B-WC) cholera vaccine and recombinant cholera toxin B subunit (CTB) alone were used as model immunogens. LÄS MER

  4. 18. The small intestine in experimental peritonitis : An experimental study focusing om intestinal energy metabolism, bacterial translocation and mucosal immunology

    Författare :Mikael Ljungdahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Bacterial translocation; endotoxin; faecal peritonitis; high-energy phosphates; hypoxia; intramucosal pH; IL-6; ischaemia; lactate; lymphocytes; mucosal injury; oxygendelivery; pigs; sepsis; tonometry; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : The gut is highly susceptible to injury during sepsis. An impaired mucosal barrier permitstranslocation of enteric microorganisms to blood or other organs. In a porcine model sepsiswas induced by faecal peritonitis. LÄS MER

  5. 19. Gastrointestinal norovirus infections and the development of the next generation of mucosal vaccines

    Författare :Inga Rimkute; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human norovirus; gastrointestinal infection; mucosal vaccine; subcomponent vaccine; human intestinal enteroids; histo-blood group antigens; lipidomics; glycoproteomics; glycosphingolipids;

    Sammanfattning : Human norovirus (HuNoV) is the causative agent of the winter vomiting disease and the leading cause of outbreaks of gastrointestinal infections across all settings and age groups in the world. The virus is highly contagious making outbreaks difficult or often impossible to control and having a high impact on societal costs and resources. LÄS MER

  7. 20. B- and T- cell responses in colectomized and healthy individuals after mucosal vaccination

    Författare :Jan Kilhamn; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestinal immunity; antibodies; interferon gamma production; ileostomy fluid; enteric vaccines; mucosal vaccination;

    Sammanfattning : The overall aims were to study the induction of intestinal and systemic B- and T-cell immune responses in patients colectomized due to ulcerative colitis and in healthy volunteers after mucosal administration of enteric vaccines. An inactivated B-subunit whole-cell (B-WC) cholera vaccine and a live attenuated Salmonella enterica serovar Typhi Ty21a vaccine were used as model immunogens. LÄS MER