Sökning: "mucosal adjuvants"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden mucosal adjuvants.

1. 1. Mucosal adjuvants and their mode of action in the female genital tract

   Författare :Madelene Lindqvist; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunology; mucosal adjuvants; genital tract; vaccine; HSV-2; mouse; alpha-galactosylceramid; CpG ODN; proteoliposome-derived cochleate; inflammation; bioinformatics;

   Sammanfattning : Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is caused by herpes simplex virus type 2 with over 536 million people infected world-wide. LÄS MER

3. 2. Nasal vaccination using novel mucosal adjuvants : with main focus on influenza A virus

   Författare :Tina Falkeborn; Jorma Hinkula; Marie Larsson; Britt Åkerlind; Anders Wallensten; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Influenza viruses have sporadically caused pandemics during the last century, with the most severe occurring in 1918 when the “Spanish flu”, an A/H1N1 influenza virus, passed around the globe killing about 20-100 million people. Today 250 000-500 000 deaths occur annually due to influenza virus or secondary infection after influenza, e.g. LÄS MER

4. 3. The development of a new combined adjuvant vector for mucosal immunization CTA1-DD/ISCOM

   Författare :Anja Helgeby; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CTA1-DD; ISCOM; adjuvants; enzyme; vaccine; B cell; Dendritic cell; T cells;

   Sammanfattning : The CTA1-DD/ISCOMs vector is a rationally designed mucosal adjuvant that was developed to host the distinctive properties of either adjuvant alone or in a combination that hosted additive enhancing effects on mucosal immune responses. Here I demonstrate that CTA1-DD can be incorporated into the ISCOM with greatly augmented immunogenicity of both incorporated and admixed antigen. LÄS MER

5. 4. Mucosal immunity in the respiratory tract : The role of IgA in protection against intracellular pathogens

   Författare :Ariane Rodríguez; Carmen Fernández; Lennart Hammarström; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosal immunity; respiratory tract; IgA; intracellular pathogens; Immunology; Immunologi;

   Sammanfattning : The lungs and upper airways are mucosal surfaces that are common site for infection with an enormous variety of inhaled pathogens. Therefore, induction of immune responses in the respiratory tract is crucial for protection against respiratory diseases. One of the pathogens infecting the host via the respiratory tract is Mycobacterium Tuberculosis. LÄS MER

7. 5. Broadly protective nanoparticle-based mucosal vaccine against influenza virus infection

   Författare :Valentina Bernasconi; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucosal vaccination; Influenza A virus; CTA1-DD; Nanoparticle; Targeted adjuvant; Nasal immunization; Oral immunization; Neonatal vaccine; Universal vaccine;

   Sammanfattning : Influenza is one of the major viral diseases affecting humans and it is responsible for three to five million cases of severe illness and about 250.000 to 500.000 deaths each year worldwide. LÄS MER