Sökning: "mucosal adjuvant"
Visar resultat 11 - 15 av 32 avhandlingar innehållade orden mucosal adjuvant.
11. Nasal vaccination using novel mucosal adjuvants : with main focus on influenza A virus
Sammanfattning : Influenza viruses have sporadically caused pandemics during the last century, with the most severe occurring in 1918 when the “Spanish flu”, an A/H1N1 influenza virus, passed around the globe killing about 20-100 million people. Today 250 000-500 000 deaths occur annually due to influenza virus or secondary infection after influenza, e.g. LÄS MER
12. Co-stimulation in gut mucosal immunity. Evidence of a differential regulationof local and systemic responses
Sammanfattning : In recent years we have learned that co-stimulatory factors are required as second signals for optimal T cell stimulation. Most types of immune responses are, therefore, dependent on the co-stimulatory signals that are provided by infection or immunization. LÄS MER
13. Cholera toxin B subunit as a carrier for inducing mucosal immunity and/or peripheral tolerance
Sammanfattning : When an antigen is introduced via a mucosal route, either immunity or tolerance, or even both may be induced. Both immunity and tolerance are actively induced phenomena and both of them could have important medical implications as well as potential prophylactic or therapeutic applications. LÄS MER
14. The development of a new combined adjuvant vector for mucosal immunization CTA1-DD/ISCOM
Sammanfattning : The CTA1-DD/ISCOMs vector is a rationally designed mucosal adjuvant that was developed to host the distinctive properties of either adjuvant alone or in a combination that hosted additive enhancing effects on mucosal immune responses. Here I demonstrate that CTA1-DD can be incorporated into the ISCOM with greatly augmented immunogenicity of both incorporated and admixed antigen. LÄS MER
15. Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
Sammanfattning : Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis spans several areas that are important for future development of mucosal vaccines. LÄS MER
