Sökning: "mu-opioid receptors"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden mu-opioid receptors.
1. DARPP-32 in the striatum : multiple regulation and physiological role
Sammanfattning : Protein phosphorylation is an important mechanism involved in intracellular signal transduction. The activity of many proteins is affected by their state of phosphorylation, which in turn is determined by the combined activities of protein kinases and protein phosphatases. LÄS MER
2. Migration of molecules in the brain : focus on the extracellular space and the cerebrospinal fluid
Sammanfattning : Three different molecules and three different experimental models were used to study the migration of molecules in the rat brain: a neurotransmitter- dopamine, an extracellular market- mannitol, and a neuropeptide beta-endorphin. Two models in vivo were used to study the diffusion and migration of molecules: dual-probe rnicrodialysis in the striatum, and direct intrastriatal microinjections followed by cerebrospinal fluid sampling from the cisterna magna. LÄS MER
3. Cerebral mechanisms in cardiovascular control : studies on haemorrhage and effects of sodium
Sammanfattning : This thesis describes experiments investigating the influence of the brain on cardiovascular adaptations to haemorrhage and excess sodium in conscious chronically prepared sheep. A continuous reduction in blood volume eventually activates a reflex that causes a fall in vascular resistance and heart rate and thereby also in arterial blood pressure. LÄS MER
4. Growth Hormone and Anabolic Androgenic Steroids : Effects on Neurochemistry and Cognition
Sammanfattning : Growth hormone (GH) stimulates growth and metabolism but also displays profound effects on the central nervous system (CNS). GH affects neurogenesis and neuroprotection, and has been shown to counteract drug-induced apoptosis in the brain. LÄS MER
5. Characterization of Substance P (SP) Aminoterminal SP (1-7) Binding in Brain Regions and Spinal Cord of the Male Rat : Studies on the Interaction with Opioid Related Pathways
Sammanfattning : Binding sites for substance P(1-7), SP(1-7) have been identified and characterized for the first time in crude membrane fraction from rat CNS using tritiated ([3H]) SP(1-7) as tracer. These putative receptors were investigated in relation to their affinity for tachykinins, opioid peptides and sigma receptor ligands. LÄS MER