Sökning: "mu metabolism"

Hittade 4 avhandlingar innehållade orden mu metabolism.

  1. 1. Migration of molecules in the brain : focus on the extracellular space and the cerebrospinal fluid

    Författare :Malin Höistad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Volume transmission; rat; diffusion; striatum; dual-probe microdialysis; delivery; recovery; clearance; uptake; dopamine; metabolism; radiotracer; mannitol; cisterna magna; opioids; peptides; betaendorphin; mu-opioid receptors; mismatch; TH; DBH; immunohistochemistry; fear.;

    Sammanfattning : Three different molecules and three different experimental models were used to study the migration of molecules in the rat brain: a neurotransmitter- dopamine, an extracellular market- mannitol, and a neuropeptide beta-endorphin. Two models in vivo were used to study the diffusion and migration of molecules: dual-probe rnicrodialysis in the striatum, and direct intrastriatal microinjections followed by cerebrospinal fluid sampling from the cisterna magna. LÄS MER

  3. 2. The kinetic mechanism of microsomal glutathione transferase 1 (MGST1)

    Författare :Richard Svensson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glutathione; glutathione transferase; enzyme mechanism; pre-steady state kinetics; steady state kinetics; membrane protein; xenobiotic metabolism.;

    Sammanfattning : Microsomal glutathione transferase I (MGST1) is a homotrimeric membrane-bound enzyme involved in detoxication of numerous toxic electrophilic compounds, e.g. halogenated alkenes and arenes, alpha, beta-unsaturated hydrocarbons and peroxides. MGST1 is expressed in large amounts in most organs, which speaks for an important role for this enzyme. LÄS MER

  4. 3. Growth Hormone and Anabolic Androgenic Steroids : Effects on Neurochemistry and Cognition

    Författare :Alfhild Grönbladh; Mathias Hallberg; Jörgen Isgaard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; anabolic androgenic steroids; nandrolone decanoate; insulin-like growth factor; GABAB; opioids; memory; water maze; autoradiography; central nervous system; rats; Biological Research on Drug Dependence; Biologisk beroendeforskning;

    Sammanfattning : Growth hormone (GH) stimulates growth and metabolism but also displays profound effects on the central nervous system (CNS). GH affects neurogenesis and neuroprotection, and has been shown to counteract drug-induced apoptosis in the brain. LÄS MER

  5. 4. Cryptogenic Polyneuropathy : Clinical, Environmental, And Genetic Studies

    Författare :Jonas Lindh; Magnus Vrethem; Göran Solders; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuropathy; Neurology; Neurologi;

    Sammanfattning : Objectives: The purpose of this medical thesis was to describe the clinical and neurophysiological features and to evaluate the health related quality of life (HR-QoL) in patients with cryptogenic polyneuropathy. We also wanted to investigate different occupational, and leisure time exposures as determinants for cryptogenic polyneuropathy, and to analyze whether polymorphisms for the null alleles of Glutathione S-Transferase Mu-1 (GSTM1), and Theta-1 (GSTT1), and a low activity genetic variation of epoxide hydrolase (EPHX) affect the risk of developing polyneuropathy. LÄS MER