Sökning: "monoamine compounds"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden monoamine compounds.
1. Lumbar puncture in psychiatric research : on the impact of confounding factors on monoamine compounds in cerebrospinal fluid
Sammanfattning : Lumbar puncture has for many years been a tool for investigations of cerebrospinal fluid (CSF) in man. The method has been in use since 1891 and is common in neurology, and other medical specialities. LÄS MER
2. Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization
Sammanfattning : It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and current therapies are still based on this mechanism. However, all available antidepressants today are still suffering from slow onset of therapeutic action, as well as adverse effects and lack of efficacy. LÄS MER
3. Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo
Sammanfattning : The endogenous neurotransmitter dopamine (DA) is involved in several functions that are controlled from the central nervous system (CNS), for example behaviour, memory, cognition and reward. A disturbed dopaminergic neurotransmission may lead to many severe conditions, such as schizophrenia, attention deficit hyperactivity disorder (ADHD) or Parkinson's disease (PD). LÄS MER
4. Development of novel fluorine-18 labeled PET radioligands for monoamine oxidase B (MAO-B)
Sammanfattning : Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selective and irreversible MAO-B inhibitors such as L-deprenyl and rasagiline are clinically used for the treatment of psychiatric and neurological disorders. LÄS MER
5. Development of 18F- and 68Ga-Labelled Tracers : Design Perspectives and the Search for Faster Synthesis
Sammanfattning : This thesis deals with the design of 18F- and 68Ga-labelled positron emission tomography (PET) tracers and the development of technologies that enable faster and simpler preparation with high specific radioactivity. Techniques like microwave heating and reducing the concentrations of the precursor were investigated with this perspective. LÄS MER