Sökning: "molecular weight increase"

Visar resultat 1 - 5 av 172 avhandlingar innehållade orden molecular weight increase.

  1. 1. The effects of glucocorticoids on brown fat : physiological and molecular studies

    Författare :Ineke Luijten; Jan Nedergaard; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Brown adipose tissue (BAT) is the main site for non-shivering thermogenesis in most mammals. The BAT-specific uncoupling protein-1 (UCP1) uncouples substrate oxidation from ATP production and hereby decreases metabolic efficiency. LÄS MER

  3. 2. Protein Interaction Studies with Low Molecular Weight Ligands : Applications for Drug Discovery, Basic Research and Diagnostic Tool Design

    Författare :Tony Christopeit; U.Helena Danielson; Danièle Altschuh; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In this thesis, the interactions between different proteins and small ligands were characterized by surface plasmon resonance spectroscopy (SPR) and fluorescence resonance energy transfer (FRET) based assays.   For the C-reactive protein (CRP), a new type of artificial binder was identified which allows designing diagnostic assays superior to commonly used standard assays. LÄS MER

  4. 3. Giant cell arteritis. Epidemiological, morphological and molecular genetic studies

    Författare :Vigdís Pétursdóttir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Giant cell arteritis; temporal artery; aorta; epidemiology; atrophy; calcification; estrogen receptor a; morphometry; immunocytochemistry; Western blot; molecular genetics;

    Sammanfattning : Giant cell arteritis (GCA) is a chronic inflammatory disorder of unknown etiology, affecting large and medium-sized arteries, predominantly in postmenopausal women. Its pathogenesis is probably multifactorial. Several studies suggest that GCA is an antigen-driven disease. LÄS MER

  5. 4. Dietary, Pharmacological and Environmental Effects on Brown Adipose Tissue

    Författare :Erik Lindsund; Tore Bengtsson; Jan Nedergaard; Karsten Kristiansen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Obesity; brown adipose tissue; uncoupling protein 1; moderate cold exposure; calorimetry; thyroxine; dietary protein; thermic effect of food; diet-induced thermogenesis; adrenergic stimulation; mice; physiology; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Obesity is a common health issue; over 12 % of the adult world population have obesity. Obesity has many co-morbidities including cardo-vascular diseases and diabetes. Obesity is the result of chronic positive energy balance, eating too much and expending too little. LÄS MER

  7. 5. Pathogenesis of Obesity and Effects of Treatment. Clinical and Molecular Studies on Body Fat, Energy Balance, and Weight Loss

    Författare :Anders Gummesson; Göteborgs universitet; []
    Nyckelord :Obesity; Adipose tissue; Obesity treatment; Energy balance; Visceral obesity; Weight loss; Cancer; Human studies;

    Sammanfattning : Obesity is common and related to many health problems including various forms of cancer. The condition arises from the imbalance between food intake and energy expenditure, and is strongly influenced by genetic factors. LÄS MER