Sökning: "molecular target"

Visar resultat 1 - 5 av 1082 avhandlingar innehållade orden molecular target.

  1. 1. Molecular Palaeopathology : Ancient DNA analyses of the bacterial diseases tuberculosis and leprosy

    Detta är en avhandling från Stockholm : Arkeologiska forskningslaboratoriet

    Författare :Emilia Nuorala; Kerstin Lidén; Ingrid Ekenman; Marie Allen; [2004]
    Nyckelord :HUMANIORA; HUMANITIES; molecular palaeopathology; ancient DNA; disease; bacteria; tuberculosis; leprosy; HUMANITIES and RELIGION History and philosophy subjects Archaeology subjects; HUMANIORA och RELIGIONSVETENSKAP Historisk-filosofiska ämnen Arkeologiämnen;

    Sammanfattning : This thesis “Molecular Palaeopathology. Ancient DNA analyses of the bacterial diseases tuberculosis and leprosy” deals with molecular palaeopathology, i.e. in this case the use of molecular methods to analyse ancient bacterial DNA in order to get further knowledge of diseases in ancient times. LÄS MER

  2. 2. Antiphagocytosis by Yersinia pseudotuberculosis role of the YopH target proteins

    Detta är en avhandling från Umeå : Molekylärbiologi

    Författare :Ming Yuan; Maria Fallman; Tommy Nilsson; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular biology; Cas; Fyb; mAbp1; SKAP-HOM; Yersinia pseudotuberculosis; YopH; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The enteropathogenic bacterium Yersinia pseudotuberculosis binds to β1 integrins on a host cell via its surface protein invasin. This event stimulates signal transduction to the actin cytoskeleton of the eukaryotic cell, which allows the cell to engulf the bacterium that is attached to its surface. However, the pathogen Y. LÄS MER

  3. 3. Molecular Approaches to Explore Drug-Target Interactions

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Abdullah Al-Amin; Ulf Landegren; Christopher Schofield; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug discovery; target engagement; target engagement-mediated amplification; cellular thermal shift assay; proximity extension assay; in situ PLA; high-content imaging; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Improved means to assess the clinical potential of drug candidates can critically influence development of new therapeutic entities, a central aim in medical life science. Drug discovery and development relies on construction and selection of small organic compounds or biological agents that bind targets of interest. LÄS MER

  4. 4. Molecular Regulation of Inflammation and Angiogenesis in the Tumor Microenvironment

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Lothar Dieterich; Anna Dimberg; Lena Claesson-Welsh; Jonas Fuxe; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; stroma; glioma; alphaB-crystallin; HSPB5; cryab; myeloid cells; MEDICINE Morphology; cell biology; pathology; MEDICIN Morfologi; cellbiologi; patologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Tumor growth and progression not only depend on properties of the malignant cells but are strongly influenced by the tumor microenvironment. The tumor stroma consists of various cell types such as inflammatory cells, endothelial cells and fibroblasts, which can either inhibit or promote tumor growth. LÄS MER

  5. 5. Molecular Signatures of Cancer

    Detta är en avhandling från Stockholm : KTH

    Författare :Esther Edlundh-Rose; Joakim Lundeberg; Peter Södervist; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; : BRAF; NRAS; MGMT; methylation; pyrosequencing; microarray technology; gene expression analysis; NATURAL SCIENCES Chemistry Biochemistry Molecular biology; NATURVETENSKAP Kemi Biokemi Molekylärbiologi;

    Sammanfattning : Cancer is an important public health concern in the western world, responsible for around 25% of all deaths. Although improvements have been made in the diagnosis of cancer, treatment of disseminated disease is inefficient, highlighting the need for new and improved methods of diagnosis and therapy. LÄS MER