Sökning: "molecular marker"
Visar resultat 21 - 25 av 389 avhandlingar innehållade orden molecular marker.
21. Biomarkers of ionising radiation relevant to carcinogenesis : Dose, dose rate and LET dependency of the responses
Sammanfattning : A better understanding of the relationship between ionising radiation (IR) dose, dose rate and radiation quality, and the risk of stochastic effects would improve risk extrapolation from atomic bomb survivors’ data. Owing to insufficient statistical power of epidemiological studies to detect excess incidence of cancer following low doses of IR delivered at low dose rates (LDLDR), as typically encountered in most common human exposure scenarios, radiobiological experiments are fundamental to describe the biological effectiveness of LDLDR and to define the underlying molecular mechanisms. LÄS MER
22. Studies of Stroma Formation and Regulation in Human Pathological Conditions and in Experimental in vivo Models
Sammanfattning : Fibrosis is a sequel of chronic inflammation and is defined as an excessive deposition of collagen that ultimately leads to organ dysfunction. To date there are no effective treatments for fibrosis. The main cell type involved in collagen deposition and organization is the myofibroblast. LÄS MER
23. Cardiomyocyte Cell Cycle, Renewal and Isolation
Sammanfattning : Heart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. LÄS MER
24. Timing Matters : Wounding and entomopathogenic nematode infection kinetics
Sammanfattning : Over time, insects have developed complex strategies to defend themselves against presenting threats. However, in the evolutionary arms race of survival, pathogens have adapted to quickly overcome the immune response mounted by the host. LÄS MER
25. Oxidized nucleotides as a predictor of radiation sensitivity
Sammanfattning : The direct and indirect effects of IR can lead to DNA damage and activation of DNA repair. The indirect effects of ionizing radiation mediated by reactive oxygen species (ROS) which produced through radiolysis of water and if not taken care of by the antioxidant system, can also give rise to oxidative stress. LÄS MER