Sökning: "molecular investigation"

Visar resultat 1 - 5 av 699 avhandlingar innehållade orden molecular investigation.

  1. 1. New Molecular Approaches to Glioblastoma Therapy

    Författare :Sathishkumar Baskaran; Sven Nelander; Karin Forsberg Nilsson; Silvia Marino; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; GBM; ZBTB16; PLZF; Heterogeneity; Proteasome inhibitors; Bortezomib; Pterostilbene; drug combinations; Oncology; Onkologi; Biological Research on Drug Dependence; Biologisk beroendeforskning; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Glioblastoma (GBM) is the most common high-grade brain tumor diagnosed in patients who are more than 50 years of age. The standard of care treatment is surgery, followed by radiotherapy and chemotherapy. The median life expectancy of patients is only between 12 to 15 months after receiving current treatment regimes. LÄS MER

  2. 2. Multivariate design of molecular docking experiments : An investigation of protein-ligand interactions

    Författare :David Andersson; Anna Linusson Jonsson; Gabriele Cruciani; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular docking; chemometrics; multivariate analysis; principal component analysis; PCA; design of experiments; DoE; partial least-square projections to latent structures; PLS; scoring functions; ligand-binding cavity; major histocompatibility complex; MHC; glycopeptide; T-cell.; Pharmaceutical chemistry; Läkemedelskemi; datorlingvistik; computational linguistics;

    Sammanfattning : To be able to make informed descicions regarding the research of new drug molecules (ligands), it is crucial to have access to information regarding the chemical interaction between the drug and its biological target (protein). Computer-based methods have a given role in drug research today and, by using methods such as molecular docking, it is possible to investigate the way in which ligands and proteins interact. LÄS MER

  3. 3. A Quantum Chemical View of Molecular and Nano-Electronics

    Författare :Jun Jiang; Yi Luo; Jim Greer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi;

    Sammanfattning : This dissertation presents a generalized quantum chemical approach for electron transport in molecular electronic devices based on Green's function scattering theory. It allows to describe both elastic and inelastic electron transport processes at first principles levels of theory, and to treat devices with metal electrodes either chemically or physically bonded to the molecules on equal footing. LÄS MER

  4. 4. Molecular Electronics - Modeling, Devices and Architecture

    Författare :Jonas Sköldberg; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Molecular electronics; memristor; self-assembly; threshold logic; switching networks; hybrid devices; NDR; hysteresis; reconfigurable logic; nanocell;

    Sammanfattning : Molecular electronics is an area of micro/nanoelectronics with a number of farreaching goals and challenges: denser implementation of electronic memory and logic, less expensive manufacturing, smaller or more sensitive measurement devices, selfassembly of devices and systems and, last but not least, exploring new science and applications.In recent years, molecular electronics has expanded into a broader field of molecular-scale electronics, partly because molecular components have to be defined in solid-state contexts via lithography and self-assembly, and effectively become hybrid devices with new and interesting properties. LÄS MER

  5. 5. Investigation of genes and proteins involved in xylan biosynthesis

    Författare :Anders Winzell; Ines Ezcurra; Johan Edqvist; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Populus; xylan biosynthesis; hemicellulose; glycosyltransferase; GT43; IRX; glycoside hydrolase; GH10; Xyn10A; CAZy; transcription factor; MYB; wood formation; secondary cell wall; Arabidopsis; Molecular biology; Molekylärbiologi;

    Sammanfattning : Wood formation or xylogenesis is a fundamental process for so diverse issues as industry, shelter and a sustainable environment. Wood is comprised of secondary xylem, rigid large cells with thick cell walls that are lignified. LÄS MER