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Visar resultat 1 - 5 av 260 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Next generation molecular diagnostics using ultrasensitive sequencing

    Författare :Stefan Filges; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Liquid biopsy; cell-free DNA; circulating tumor DNA; molecular diagnostics; next-generation sequencing; unique molecular identifiers; melanoma;

    Sammanfattning : Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to revolutionize molecular diagnostics. LÄS MER

  3. 2. Advancing isothermal nucleic acid amplification tests : Towards democratization of diagnostics

    Författare :Felix Neumann; Mats Nilsson; Paul Yager; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molecular diagnostics; infectious diseases; point-of-care; digital quantification; fluorescence detection; rolling circle amplification; padlock probes; microfluidic enrichment; Biochemistry; biokemi;

    Sammanfattning : Modern healthcare is the result of scientific advancement across disciplines and has enabled us to understand the rationale behind many diseases and how to treat or cure them; but still a myriad of unanswered questions remains. Especially infectious diseases play an important role in healthcare as they pose a constant threat for global health and well-being. LÄS MER

  4. 3. Diagnostics for advanced fusion plasma scenarios

    Författare :Mattias Kuldkepp; Elisabeth Rachlew-Källne; Fritz Wagner; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MSE; PEM; mirror evolution; fusion; diagnostics; plasma spectroscopy; reversed field pinch; spherical tokamak; intelligent shell; PPCD; MAST; ITER; Molecular physics; Molekylfysik;

    Sammanfattning : Over the past decade, fusion research has showed the potential of being a main candidate for energy production for future generations. Further advances in improved fusion performance are therefore vital. This thesis focuses on advanced fusion plasma scenarios and their diagnostic requirements. LÄS MER

  5. 4. Padlock Probe-Based Nucleic Acid Amplification Tests : Point-of-care Diagnostics of Infectious Diseases

    Författare :Sibel Ciftci; Mats Nilsson; Jonas Klingström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nucleic Acid Amplification; Isothermal Amplification Methods; Padlock Probes; Rolling Circle Amplification; Molecular Diagnostics; Infectious Disease Diagnostics; Virus; Point-of-Care; Biochemistry; biokemi;

    Sammanfattning : Recent advancements in molecular biology and biotechnology have pushed the field of molecular diagnostics much further to benefit the society towards smart access for rapid and simplified health care. In this context, point-of-care (PoC) technologies that bring the inventions in diagnostics closer to bedside settings draw attention. LÄS MER

  7. 5. Dried blood sampling and digital readout to advance molecular diagnostics

    Författare :Johan Björkesten; Ulf Landegren; Björn Högberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; molecular diagnostics; dried blood sample; DBS; digital readout; digital enumeration; DNA detection methods; proximity extension assay; protein stability; genotyping; rare mutations; cell free DNA; multiplex protein measurement.; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : A drastically increased capacity to measure large sets of molecular features in numerous patient samples in great detail will be required to fulfill the vision of precision medicine and wellness, which may characterize molecular diagnostics in the 21st century. Also sampling procedures need a renaissance to permit continuous sampling at population levels at reasonable cost. LÄS MER