Sökning: "molecular biomarkers"

Visar resultat 16 - 20 av 330 avhandlingar innehållade orden molecular biomarkers.

  1. 16. Molecular Epidemiology of Cardiovascular Disease

    Författare :Markus Stenemo; Johan Ärnlöv; Rikard Landberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomarkers; ischemic stroke; heart failure; omics; proteomics; metabolomics; epidemiology; risk marker; Epidemiologi; Epidemiology;

    Sammanfattning : Cardiovascular disease is a major cause of morbidity and mortality, with increasing prevalence worldwide.Identification of risk markers may enable improved prevention by targeting high-risk individuals, earlier disease diagnosis and treatment, as well as stratification of disease subtypes with different treatment options, thereby minimizing side effects while increasing success rates. LÄS MER

  3. 17. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers

    Författare :Iliana Kyriaki Kerzeli; Sara Mangsbo; Tania de Gruijl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; Tumor immunology; MALT1 inhibition; Urothelial bladder cancer; Tumor microenvironment; Immunologi; Immunology; Oncology; Onkologi; Urologi; Urology;

    Sammanfattning : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. LÄS MER

  4. 18. Radiation induced biomarkers of individual sensitivity to radiation therapy

    Författare :Sara Skiöld; Mats Harms-Ringdahl; Siamak Haghdoost; Mats Ljungman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; low dose ionizing radiation; radiation sensitivity; proteomics; whole blood; 8-oxo-dG; oxidative stress; acute adverse healthy tissue effects; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Fifty percent of solid cancers are treated with radiation therapy (RT). The dose used in RT is adjusted to the most sensitive individuals so that not more than 5% of the patients will have severe adverse healthy tissue effects. LÄS MER

  5. 19. Application and interpretation of biomarkers in ecotoxicology - from molecular to individual level responses

    Författare :Sara Furuhagen; Elena Gorokhova; Carlos Barata; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biomarkers; oxidative stress; ORAC; reproduction; Daphnia magna; toxicity; environmental stress; Applied Environmental Science; tillämpad miljövetenskap;

    Sammanfattning : The use of biomarkers is considered a promising alternative, or complement, to traditional ecotoxicological assays. Toxic effects are often initially manifested at the molecular or biochemical level, biomarkers are therefore used as sensitive indicators of toxic exposure. LÄS MER

  7. 20. Technological Advancements in Affinity Proteomics : From planar antibody microarrays towards a solution-based platform

    Författare :Mattias Brofelth; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Affinity proteomics; Antibody microarrays; scFv; Biomarkers; MIAS;

    Sammanfattning : Abstract: Proteomics has the potential to deliver disease-associated biomarkers that could provide diagnostic, prognostic and predictive information to enable precision medicine. Affinity proteomics, most commonly based on antibodies and their ability to specifically capture target proteins, has emerged has a valuable tool in biomarker discovery. LÄS MER