Sökning: "model library design"
Visar resultat 21 - 25 av 62 avhandlingar innehållade orden model library design.
21. Structural studies and design of Di-iron carboxylate proteins
Sammanfattning : Di-iron carboxylate proteins perform a wide range of chemical reactions in the cell. These reactions often involve activation of dioxygen to generate highly oxidative species that can be used in catalysis. One member of the di-iron carboxylate family is the enzyme ribonucleotide reductase (RNR). LÄS MER
22. High-Level Synthesis for SiLago : Advances in Optimization of High-Level Synthesis Tool and Neural Network Algorithms
Sammanfattning : Embedded hardware designs and their automation improve energy and engineering efficiency. However, these two goals are often contradictory. The attempts to improve energy efficiency often come at the cost of engineering efficiency and vice-versa. High-level synthesis (HLS) is a good example of this challenge. LÄS MER
23. Development and Application of Computational Methods in Antitubercular Drug Design : Identification of Novel Inhibitors of Ribonucleotide Reductase
Sammanfattning : Tuberculosis kills approximately 1.7 million people each year around the world making it one of the most lethal infectious diseases. This thesis concerns the development of two computational tools that can support the early stages of drug discovery, and their use in an anti-tubercular drug discovery program. LÄS MER
24. Engineering Candida antarctica Lipase A for Enantioselective Transformations in Organic Synthesis : Design, Immobilization and Organic Solvent Screening of Smart Enzyme Libraries
Sammanfattning : The use of enzymes as catalysts in organic synthesis constitutes an attractive alternative to conventional chemical catalysis. Enzymes are non-toxic and biodegradable and they can operate under mild reaction conditions. LÄS MER
25. Expression of a lipase in prokaryote and eukaryote host systems allowing engineering
Sammanfattning : Pseudozyma (Candida) antarctica lipase B (PalB) was expressed in Escherichia coli facilitating protein engineering. The lack of glycosylation was evaluated for a deeper understanding of the difficulties in expressing PalB in E. coli. LÄS MER