Sökning: "mixed effects modeling"

Visar resultat 1 - 5 av 62 avhandlingar innehållade orden mixed effects modeling.

  1. 1. Contributions to nonlinear mixed-effects modeling

    Författare :Jacob Leander; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nonlinear mixed-effects models; stochastic differential equations; parameter estimation; extended Kalman filter; sensitivity equations; stochastic differential equations;

    Sammanfattning : The topic of this thesis is nonlinear mixed-effects models. A nonlinear mixed-effects model is a hierarchical regression model used to analyze measurements from several individuals simultaneously, which allows sharing of information between similar individuals. LÄS MER

  3. 2. Nonlinear Mixed Effects Modeling of Combination Therapies in Oncology

    Författare :Marcus Baaz; Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC); []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacol- ogy; Radiation Therapy; Oncology; Mathematical Modeling; Combination Therapy; Nonlinear Mixed Effects;

    Sammanfattning : It has been shown that simultaneous administration of two or more anticancer agents can have a beneficial effect on cancer patients. This type of treatment is called combination therapy and is nowadays commonly used in the fight against cancer. LÄS MER

  4. 3. Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems - Methods and Applications in Drug Development

    Författare :Jacob Leander; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pharmacometrics; pharmacokinetics; mixed effects; drug development; pharmacodynamics; parameter estimation; time-to-event; mathematical modeling; dynamical systems;

    Sammanfattning : Mathematical models based on ordinary differential equations (ODEs) are commonly used for describing the evolution of a system over time. In drug development, pharmacokinetic (PK) and pharmacodynamic (PD) models are used to characterize the exposure and effect of drugs. LÄS MER

  5. 4. Covariate Model Building in Nonlinear Mixed Effects Models

    Författare :Jakob Ribbing; E. Niclas Johnsson; Mats O. Karlsson; Janet Wade; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Modeling; Covariate selection; Stepwise selection; Covariate analysis; Methodology; Model validation; Model evaluation; Type-2 diabetes; Beta-cell function; Meta analysis; Cross-validation; Least absolute shrinkage and selection operator; Pharmacometrics; ED optimization; Farmakokinetik Farmakoterapi;

    Sammanfattning : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. LÄS MER

  7. 5. Data-driven modeling of combination therapy in oncology

    Författare :Tim Cardilin; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Model-Based Drug Development; Pharmacokinetics Pharmacodynamics; Nonlinear Mixed-Effects Models; Combination Therapy; Mathematical Modeling; Nonlinear Mixed-Effects Models;

    Sammanfattning : This thesis contains two manuscripts: Tumor Static Concentration Curves in Combination Therapy and Extending the Tumor Static Concentration Curve to Exposure - A Combination Therapy Example with Radiation Therapy. There is also an introductory chapter presenting some basic facts necessary to understand the appended manuscripts. LÄS MER