Sökning: "mitotic activity"

Visar resultat 1 - 5 av 49 avhandlingar innehållade orden mitotic activity.

  1. 1. Cyclooxygenase activity and tumor progression

    Författare :Christian Cahlin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclooxugenase; PGE2; inflammation; cytokine; nitric oxide; indomethacin; IL-6;

    Sammanfattning : Invasive growth of malignant tumors is associated with local and systemic inflammation, which may promote progression and metastases. Inflammation is also responsible for appearing manifestations of advanced cancer as fatigue, anorexia and wasting with eicosanoids, proinflammatory cytokines and nitric oxide as mediators. LÄS MER

  3. 2. Regulation of CDK dephosphorylation in mitotic entry

    Författare :Arne Lindqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cell cycle progression is orchestrated by the activity of a Cyclin dependent kinase (Cdk) in complex with a Cyclin. The key regulator of early mitotic events is the Cyclin B1/Cdk1 complex. In G2, Cyclin B1/Cdk1 is kept inactive by phosphorylation in the active site of Cdk1. LÄS MER

  4. 3. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

    Författare :Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

    Sammanfattning : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. LÄS MER

  5. 4. Regulation of tubulin heterodimer partitioning during interphase and mitosis

    Författare :Per Holmfeldt; Martin Gullberg; Pontus Aspenström; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; microtubule; mitotic spindle; signal transduction; phosphorylation; cancer; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : The microtubule cytoskeleton, which consists of dynamic polymers of alpha/beta tubulin heterodimers, organizes the cytoplasm and is essential for chromosome segregation during mitosis. My thesis addresses the significance and potential interplay between four distinct microtubule-regulatory proteins. LÄS MER

  7. 5. Cell cycle regulation and DNA damage response : a record of polo-like kinase 1 activity

    Författare :Elvira Hukasova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Division and cell proliferation is an essence of life. A human cell has in its core a very simple yet a very complex machinery to coordinate cell cycle activities and events. LÄS MER