Sökning: "mitogen-activated protein kinase"
Visar resultat 21 - 25 av 95 avhandlingar innehållade orden mitogen-activated protein kinase.
21. Role of the map kinase pathways in maintenance of the transformed phenotype
Sammanfattning : In order to interfere pharmacologically with tumor growth and metastasis, it is of great importance to understand the status of the signal transduction systems in tumor cells. The effect of various oncogenes on cellular signal transduction events has largely been studied in short term experiments. LÄS MER
22. The role of glucocorticoid receptors and mitogen-regulated protein kinases in the cochlea
Sammanfattning : Hearing loss induced by acoustic trauma is a common handicap for the human population. Acoustic trauma triggers a cascade of changes in the cochlea such as a direct mechanical damage of sensory hair cells, biochemical disturbances including reactive oxygen and nitrogen species generation, release of pro-inflammatory cytokines and exitotoxicity. LÄS MER
23. A Path for Improving Stroke Recovery. Effects of MEK-ERK1/2 Inhibition
Sammanfattning : The present thesis aimed to shed more light on the notion of acute inhibition of extracellular-signal regulated kinase (ERK)1/2 pathway as a treatment to improve stroke recovery. Stroke is a major cause of death and long-term disability worldwide, classified as ischemic or hemorrhagic. LÄS MER
24. Serine / threonine protein phosphatase 5 – a double-edged sword : in the progression towards diabetes
Sammanfattning : Type 2 diabetes mellitus is increasing at an alarming rate worldwide. In the development and progression of type 2 diabetes mellitus, the insulin-producing pancreatic β-cells are commonly exposed to a hyperglycemic and hyperlipidemic environment, in which the levels of reactive oxygen species are elevated. LÄS MER
25. Diabetogenic effects of glucocorticoids : role of protein phosphatase 5 and GLP-1 receptor activation
Sammanfattning : Obesity, the metabolic syndrome and type 2 diabetes are inextricably linked together, and all increase with rapid pace globally. Glucocorticoid (GC) excess is associated with diabetogenic effects, including insulin resistance and glucose intolerance, and a role for GCs has also been proposed in the development and pathology of the metabolic syndrome. LÄS MER