Sökning: "mitogen activated protein kinase"

Visar resultat 21 - 25 av 99 avhandlingar innehållade orden mitogen activated protein kinase.

  1. 21. Uncoupling Proteins : Regulation by IGF-1 and Neuroprotection during Hyperglycemia in Vitro

    Författare :Helena Gustafsson; Anna Forsby; David Tomlinson; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; uncoupling protein; oxidative stress; diabetes; neuropathy; SH-SY5Y; Neurobiology; Neurobiologi;

    Sammanfattning : Diabetic neuropathy is believed to arise due to oxidative stress following hyperglycemic situations. Uncoupling proteins (UCPs) constitute a subgroup of mitochondrial transporter proteins with putative antioxidant properties. LÄS MER

  3. 22. Regulation and Function of MAP Kinases in PDGF Signaling

    Författare :Glenda Eger; Johan Lennartsson; Carl-Henrik Heldin; Martin Gullberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; MAP kinase; Erk1 2; Erk5; Dusp MKP; NR4A1; cancer; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. LÄS MER

  4. 23. Role of the map kinase pathways in maintenance of the transformed phenotype

    Författare :Sofia Ljungdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ras; c-jun; MAPK; carcinogenesis; transformation;

    Sammanfattning : In order to interfere pharmacologically with tumor growth and metastasis, it is of great importance to understand the status of the signal transduction systems in tumor cells. The effect of various oncogenes on cellular signal transduction events has largely been studied in short term experiments. LÄS MER

  5. 24. Serine / threonine protein phosphatase 5 – a double-edged sword : in the progression towards diabetes

    Författare :Nina Grankvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :diabetes;

    Sammanfattning : Type 2 diabetes mellitus is increasing at an alarming rate worldwide. In the development and progression of type 2 diabetes mellitus, the insulin-producing pancreatic β-cells are commonly exposed to a hyperglycemic and hyperlipidemic environment, in which the levels of reactive oxygen species are elevated. LÄS MER

  7. 25. Diabetogenic effects of glucocorticoids : role of protein phosphatase 5 and GLP-1 receptor activation

    Författare :Liselotte Fransson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity, the metabolic syndrome and type 2 diabetes are inextricably linked together, and all increase with rapid pace globally. Glucocorticoid (GC) excess is associated with diabetogenic effects, including insulin resistance and glucose intolerance, and a role for GCs has also been proposed in the development and pathology of the metabolic syndrome. LÄS MER