Sökning: "mitochondrial quality control"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden mitochondrial quality control.

1. 1. The interactome of the yeast mitochondrial ribosome : Organization of mitochondrial post-transcriptional regulation, membrane protein insertion and quality control

   Författare :Braulio Vargas Möller-Hergt; Martin Ott; Michal Minczuk; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitochondrial post-transcriptional regulation; mitochondrial ribosome; membrane protein insertion; mitochondrial quality control; Biochemistry; biokemi;

   Sammanfattning : The proteins found in mitochondria originate from two different genetic systems. Most mitochondrial proteins are synthesized in the cytosol and post-translationally imported into the organelle. However, a small subset of mitochondrial proteins is encoded in an organelle-resident genome. LÄS MER

3. 2. Mitochondrial translation and its impact on protein homeostasis and aging

   Författare :Tamara Suhm; Martin Ott; Aleksandra Trifunovic; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondrial ribosome; mitochondrial translation accuracy; mitochondrial communication; interorganellar communication; stress signaling; proteostasis; aging; yeast genetics; mitochondrial protein quality control; mitochondrial membrane protein insertion; Biochemistry; biokemi;

   Sammanfattning : Besides their famous role as powerhouse of the cell, mitochondria are also involved in many signaling processes and metabolism. Therefore, it is unsurprising that mitochondria are no isolated organelles but are in constant crosstalk with other parts of the cell. LÄS MER

4. 3. Mitochondrial Genome Analysis Using Next Generation Sequencing for Forensic Applications

   Författare :Kimberly Sturk-Andreaggi; Marie Allen; Antti Sajantila; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mitochondrial DNA; next generation sequencing; massively parallel sequencing; forensic genetics; nuclear mitochondrial DNA segment NUMT ; length heteroplasmy; haplogroup; quality control; population data; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : Mitochondrial DNA (mtDNA) analysis plays a specialized role in forensic applications, overcoming certain limitations of autosomal DNA markers. The high copy number and uniparental inheritance pattern of mtDNA are advantageous in cases involving shed hairs and aged skeletal elements, especially decades-old missing persons cases. LÄS MER

5. 4. Adaptation and Protein Quality Control Under Metalloid Stress

   Författare :Sebastian Ibstedt; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein quality control; arsenite; tellurite; natural selection; Saccharomyces cerevisiae;

   Sammanfattning : Toxic metals and metalloids are emerging as major environmental pollutants, having ecological consequences as well as being linked to a broad range of degenerative conditions in animals, plants and humans. While the toxicity of several metalloids is well established, the underlying molecular mechanisms are often not clear. LÄS MER

7. 5. Interconnectivity of mitochondrial protein biogenesis and homeostasis

   Författare :Carmela Vázquez Calvo; Martin Ott; Jan Riemer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondria; proteostasis; protein quality control; chaperones; biokemi; Biochemistry;

   Sammanfattning : To ensure correct protein function, the cells are equipped with a tightly regulated network of chaperones that support protein folding and actively participate in protein quality control (PQC) and turnover. Due to the dual origin of the mitochondrial proteome, the cytosolic and mitochondrial PQC networks coordinate to ensure protein import and assembly in the organelle. LÄS MER