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Visar resultat 1 - 5 av 77 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Regulation of proton-coupled electron transfer in cytochrome c oxidase : The role of membrane potential, proton pathways and ATP

   Författare :Markus Björck; Peter Brzezinski; Thorsten Friedrich; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; charge transfer; membrane potential; membrane protein; mitochondria; ATP; proton pump; Biochemistry; biokemi;

   Sammanfattning : Cytochrome c oxidase (CytcO) is the final electron acceptor of the respiratory chain. In this chain a current of electrons, derived from degradation of nutrients, along with protons, are used to reduce oxygen to water. The reaction is exergonic and the excess energy is used to pump protons across the membrane. LÄS MER

3. 2. Sperm Membrane Channels, Receptors and Kinematics : Using boar spermatozoa for drug toxicity screening

   Författare :Alejandro Vicente Carrillo; Heriberto Rodríguez-Martínez; Karl-Eric Magnusson; Rudolf Rigler; Vesa Loitto; Stefan Arver; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Plasma membrane; membrane channels; membrane receptors; kinematics; 3Rprinciples; spermatozoa; boar.;

   Sammanfattning : Internal fertilization usually implies that a spermatozoon, with intact attributes for zygote formation, passes all hurdles during its transport through the female genitalia and reaches the oocyte. During this journey, millions to billions of other spermatozoa perish. LÄS MER

4. 3. Insight into the mitochondrial apoptotic pathway : The interplay of the pro-apoptotic Bax protein with oxidized phospholipids and its counterplayer, the pro-survival Bcl-2 protein

   Författare :Marcus Wallgren; Gerhard Gröbner; Marco Colombini; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; apoptosis; Bax; Bcl-2; CD; cell-free protein synthesis; DSC; membrane; mitochondria; oxidized phospholipids; reconstitution; solid state NMR; biologisk kemi; biological chemistry;

   Sammanfattning : Apoptosis plays a crucial role in multicellular organisms by preserving tissue homeostasis and removing harmful cells. The anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and the pro-apoptotic Bcl-2-associated X protein (Bax) act as major regulators of the mitochondrial apoptotic pathway. LÄS MER

5. 4. Cell-penetrating peptide targeting mitochondria : Design, synthesis, characterization, and biological effects

   Författare :Carmine Pasquale Cerrato; Ülo Langel; Lena Mäler; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptide; mitochondrial targeting; ROS reduction; mitochondrial membrane potential; antioxidant activity; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : More than twenty years after the discovery of the first cell-penetrating peptide (CPP), a large number of both naturally occurring as well as engineered CPPs have been discovered. Generally, CPPs are short polycationic sequences of less than 30 amino acids that are able to translocate different cargoes into cells. LÄS MER

7. 5. The role of the mitochondrial membrane system in apoptosis : the influence of oxidative stress on membranes and their interactions with apoptosis-regulating Bcl-2 proteins

   Författare :Martin Lidman; Gerhard Gröbner; Magnus Wolf-Watz; Philip Williamson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bax; Bc-2; apoptosis; mitochondria; membranes; oxidized lipids; NMR; calorimetry; circular dichroism; biokemi; Biochemistry; fysikalisk kemi; Physical Chemistry;

   Sammanfattning : Apoptosis is a crucial process in multicellular organisms in sculpting them, especially during embryogenesis. In addition, apoptosis is responsible for the clearance of harmful or damaged cells which can otherwise be detrimental to the organism. LÄS MER