Sökning: "mitochondrial dysfunction"

Visar resultat 1 - 5 av 107 avhandlingar innehållade orden mitochondrial dysfunction.

1. 1. Mitochondrial dysfunction in neurodegeneration

   Författare :Mats Ekstrand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Mitochondria; TFAM; Parkinson s disease; neurodegeneration;

   Sammanfattning : The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). LÄS MER

3. 2. Mitochondrial dysfunction and metabolic intervention

   Författare :Johannes Ehinger; Mitokondriell Medicin; []
   Nyckelord :Mitochondrial Diseases; Huntington Disease; Amyotrophic lateral sclerosis; Succinate; Neurodegenerative disease; Inborn errors of metabolism; Mitochondria; Animal models;

   Sammanfattning : .... LÄS MER

4. 3. Systems biology of mitochondrial dysfunction

   Författare :Florian A Schober; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The human body consumes vast amounts of metabolites that are transformed into one another, modified to useful building blocks and broken down to harvest their energy. Mitochondria are at the core of this metabolic turnover and oxidative phosphorylation provides most cellular ATP in almost all human tissues. LÄS MER

5. 4. Mitochondrial dysfunction and treatment strategies

   Författare :Shuba Krishnan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The mitochondria are essential for cellular energy production and are involved in many processes in the cells. The mitochondria contain their own DNA (mtDNA) that is vital for oxidative phosphorylation since it encodes enzymes of the respiratory chain. LÄS MER

7. 5. Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse

   Författare :Sarah Piel; Klinisk neurofysiologi; []
   Nyckelord :mitochondria; drug-induced mitochondrial toxicity; mitochondrial disease; mitochondrial medicine; drug development; succinate; methylene blue; metformin; acetaminophen; paracetamol; Kolliphor® EL;

   Sammanfattning : Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. LÄS MER