Sökning: "mitochondrial bioenergeties"

Hittade 1 avhandling innehållade orden mitochondrial bioenergeties.

1. 1. The pathophysiology of respiratory chain dysfunction

   Författare :José Pablo Silva; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcription factor A Tfam ; Cre-loxP; conditional knockout; reactive oxygen species ROS ; superoxide; uncoupling protein UCP ; mitochondrial bioenergeties; energy expenditure;

   Sammanfattning : Mutations of mitochondrial DNA cause a variety of clinical syndromes. It is unclear whether impaired oxidative phosphorylation on its own is the main cause of pathology or whether other factors such as secondary metabolic alterations, enhanced formation of reactive oxygen species (ROS) and induction of apoptosis also may contribute to the clinical phenotype. LÄS MER