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Visar resultat 1 - 5 av 18 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Thymidylate synthase expression and mismatch repair protein expression in colorectal cancer

    Författare :Katarina Öhrling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumour, node, metastasis (TNM) system, with the current staging and risk stratification methods for prognostication in colorectal cancer (CRC) has its limitations. The need for additional validated prognostic and predictive markers is particularly important in CRC stage II and III as some of these patients can be cured by surgery alone. LÄS MER

  3. 2. Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch Syndrome

    Författare :Patrick Joost; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mismatch repair; Lynch syndrome; immunohistochemistry; microsatellite instability; heterogeneity; cumulative incidence; colorectal cancer; urothelial cancer; prostate cancer; renal cell cancer;

    Sammanfattning : Mismatch repair (MMR) deficiency is carcinogenic and can either have somatic/sporadic causes (i.e. epigenetic silencing or somatic inactivation) or hereditary causes (Lynch syndrome due to a germline mutation in one of the MMR genes ¬- MLH1, MSH2, MSH6, PMS2). LÄS MER

  4. 3. Prognostic factors in colorectal cancer : studies of thymidylate synthase expression, mismatch repair protein expression, tumor budding and t-cell infiltration

    Författare :Mia Karlberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is a major health problem in the Western world. CRC is treatable with surgery and often curable when the disease is diagnosed at an early stage. With improved surgery and adjuvant chemotherapy treatment, the disease-free-survival (DFS) rate for colon cancer is approximately 80% for stage II and for stage III close to 65%. LÄS MER

  5. 4. Genotoxic effects of systemic chemotherapy in cancer patients, with special focus on the relation between MSI, LOH and development of secondary cancers

    Författare :Nasir K. Kamat; Ulf Rannug; Giovanni Corso; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemotherapy; Genetic instability; Microsatellites instability; Loss of heterozygosity; Mismatch repair; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Systemic chemotherapy results in both phenotypic and genotypic side effects. Genotoxicity posed by chemotherapy is a major concern since it induces DNA damage and instability in the patients’ genome. LÄS MER

  7. 5. DNA methylation in the placenta and in cancerwith special reference to folate transporting genes

    Författare :Sanja Farkas; Torbjörn Nilsson; Lars Breimer; Warren D. Kruger; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; CRC; placenta; cervix; leukocytes; T-DMRs; folate; array; expression; Biomedicin; Biomedicine;

    Sammanfattning : DNA methylation is an epigenetic mechanism that regulates the gene transcription. Folate is used in cellular synthesis of methyl groups, nucleic acids and amino acids. In complex diseases like cancer and neural tube defects (NTD), various genetic and epigenetic alterations can be found that disrupt the normal cell function. LÄS MER